Literature DB >> 10843587

Cytotoxic lavandulyl flavanones from Sophora flavescens.

T H Kang1, S J Jeong, W G Ko, N Y Kim, B H Lee, M Inagaki, T Miyamoto, R Higuchi, Y C Kim.   

Abstract

Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.

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Year:  2000        PMID: 10843587     DOI: 10.1021/np990567x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  16 in total

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Journal:  J Am Chem Soc       Date:  2011-11-29       Impact factor: 15.419

2.  Inhibition of growth of Streptococcus mutans, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant enterococci by kurarinone, a bioactive flavonoid isolated from Sophora flavescens.

Authors:  Li Chen; Xiaofang Cheng; Wenyuan Shi; Qingyi Lu; Vay Liang Go; David Heber; Lili Ma
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3.  Isolation and structure elucidation of a flavanone, a flavanone glycoside and vomifoliol from Echiochilon fruticosum growing in Tunisia.

Authors:  S Hammami; H Ben Jannet; A Bergaoui; L Ciavatta; G Cimino; Z Mighri
Journal:  Molecules       Date:  2004-06-30       Impact factor: 4.411

4.  Characterization of leachianone G 2"-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures.

Authors:  Ping Zhao; Kenichiro Inoue; Isao Kouno; Hirobumi Yamamoto
Journal:  Plant Physiol       Date:  2003-10-09       Impact factor: 8.340

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6.  Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells.

Authors:  Ok Won Seo; Jung Hwan Kim; Kwang Soon Lee; Kyu Sun Lee; Ji Hee Kim; Moo Ho Won; Kwon Soo Ha; Young Guen Kwon; Young Myeong Kim
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Journal:  Evid Based Complement Alternat Med       Date:  2011-08-07       Impact factor: 2.629

8.  Involvement of Transient Receptor Potential Melastatin 7 Channels in Sophorae Radix-induced Apoptosis in Cancer Cells: Sophorae Radix and TRPM7.

Authors:  Byung Joo Kim
Journal:  J Pharmacopuncture       Date:  2012-09

9.  Effects of sophorae radix on human gastric and colorectal adenocarcinoma cells: sophorae radix and cancer cells.

Authors:  Min-Chul Kim; Bora Lim; Hee-Jung Lee; Hyung-Woo Kim; Young-Kyu Kwon; Byung-Joo Kim
Journal:  J Pharmacopuncture       Date:  2012-06

10.  Antitumor activities of kushen: literature review.

Authors:  Mingyu Sun; Hongyan Cao; Lin Sun; Shu Dong; Yanqin Bian; Jun Han; Lijun Zhang; Shuang Ren; Yiyang Hu; Chenghai Liu; Lieming Xu; Ping Liu
Journal:  Evid Based Complement Alternat Med       Date:  2012-08-28       Impact factor: 2.629

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