Literature DB >> 10843223

Phosphonamidate and phosphothioate dipeptides as potential inhibitors of VanX.

K W Yang1, J J Brandt, L L Chatwood, M W Crowder.   

Abstract

In an effort to prepare novel inhibitors of VanX, N-[(1-aminoethyl)hydroxyphosphinyl]-D-alanine 1 and S-[(aminoethyl)hydroxyphosphinyl]-thiolacetic acid 2 were synthesized and evaluated as inhibitors of VanX. Phosphonamidate 1 was shown to be a partial competitive inhibitor of VanX with a Ki of 36+/-3 microM, and phosphothioate 2 was shown not to inhibit VanX.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10843223     DOI： 10.1016/s0960-894x(00)00186-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme.

Authors:  Megan L Matthews; Gopalraj Periyannan; Christine Hajdin; Tara K Sidgel; Brian Bennett; Michael W Crowder
Journal:  J Am Chem Soc       Date:  2006-10-11       Impact factor: 15.419

2.  Specificity of induction of the vanA and vanB operons in vancomycin-resistant enterococci by telavancin.

Authors:  Craig M Hill; Kevin M Krause; Stacey R Lewis; Johanne Blais; Bret M Benton; Mathai Mammen; Patrick P Humphrey; Alfred Kinana; James W Janc
Journal:  Antimicrob Agents Chemother       Date:  2010-04-19       Impact factor: 5.191

Review 3.  Glycopeptide antibiotics: from conventional molecules to new derivatives.

Authors:  Françoise Van Bambeke; Yves Van Laethem; Patrice Courvalin; Paul M Tulkens
Journal:  Drugs       Date:  2004       Impact factor: 9.546

4.  New β-phospholactam as a carbapenem transition state analog: Synthesis of a broad-spectrum inhibitor of metallo-β-lactamases.

Authors:  Ke-Wu Yang; Lei Feng; Shao-Kang Yang; Mahesh Aitha; Alecander E LaCuran; Peter Oelschlaeger; Michael W Crowder
Journal:  Bioorg Med Chem Lett       Date:  2013-09-08       Impact factor: 2.823
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.