| Literature DB >> 10843208 |
R Mandler1, E Dadachova, J K Brechbiel, T A Waldmann, M W Brechbiel.
Abstract
Geldanamycin was modified with 1,4-diaminobutane to introduce a primary amine that was subsequently employed to provide a maleimide for protein linkage. Monoclonal antibody Herceptin was then derivatized to generate thiol groups that reacted with the maleimide derivative to produce the immunoconjugate. The product showed antiproliferative activity greater than native Herceptin.Entities:
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Year: 2000 PMID： 10843208 DOI： 10.1016/s0960-894x(00)00155-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823