| Literature DB >> 10843205 |
F M Uckun1, C Mao, A O Vassilev, C S Navara, R K Narla, S T Jan.
Abstract
A novel mono-THF containing synthetic anticancer drug (WHI-261) was designed for targeting a previously unrecognized unique narrow binding cavity on the surface of tubulin. The anti-cancer activity of WHI-261 was confirmed using MTT assays. The structure-based design, synthesis, and biological activity of WHI-261 are reported.Entities:
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Year: 2000 PMID： 10843205 DOI： 10.1016/s0960-894x(00)00148-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823