Literature DB >> 10843202

Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.

Z Y Yang1, Y Xia, P Xia, A Brossi, L M Cosentino, K H Lee.   

Abstract

DCK lactam analogues were synthesized and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values of 0.00024 microM and 119,333, respectively.

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Year:  2000        PMID： 10843202     DOI： 10.1016/s0960-894x(00)00126-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.

Authors:  Jian Tang; Keduo Qian; Bei-Na Zhang; Ying Chen; Peng Xia; Donglei Yu; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2010-04-29       Impact factor: 3.641

Review 2.  Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Authors:  Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

3.  Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues.

Authors:  Ying Chen; Ming Cheng; Fa-Qiang Liu; Peng Xia; Keduo Qian; Donglei Yu; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Eur J Med Chem       Date:  2011-08-04       Impact factor: 6.514

4.  Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors.

Authors:  I Kostova; S Raleva; P Genova; R Argirova
Journal:  Bioinorg Chem Appl       Date:  2006-02-23       Impact factor: 7.778

Review 5.  Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease.

Authors:  Zhoupeng Li; Dehui Kong; Yongsheng Liu; Mingkai Li
Journal:  Genes Dis       Date:  2021-04-20
  5 in total

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