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Literature DB >> 1084314

T cell depletion in untreated adult coeliac disease.

D P O'Donoghue, M Lancaster-Smith, P Laviniere, P J Kumar.

Abstract

The proportional and absolute numbers of circulating thymus dependent lymphocytes (T cells) were reduced in untreated patients with coeliac disease but were normal after treatment with a gluten free diet. There was an inverse correlation between circulating T cell numbers and jejunal intraepithelial lymphocytes. This evidence suggests a possible role for T cells in the pathogenesis of coeliac disease and is a further example of disturbed cell mediated immunity in this condition.

Entities: Disease Species

Mesh：

Substances：
Glutens

Year: 1976 PMID： 1084314 PMCID： PMC1411143 DOI： 10.1136/gut.17.5.328

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

15 in total

1. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE.

Authors: W RUBIN; A S FAUCI; S F MARVIN; M H SLEISENGER; G H JEFRIES
Journal: J Clin Invest Date: 1965-03 Impact factor: 14.808

2. Proceedings: Coeliac disease, malignancy, and gluten-free diet.

Authors: G K Holmes; P L Stokes; R McWalter; J A Waterhouse; W T Cooke
Journal: Gut Date: 1974-04 Impact factor: 23.059

3. The jejunal cellular infiltrate in coeliac disease complicated by lymphoma.

Authors: R Ferguson; P Asquith; W T Cooke
Journal: Gut Date: 1974-06 Impact factor: 23.059

4. Malignancy in adult coeliac disease and idiopathic steatorrhoea.

Authors: O D Harris; W T Cooke; H Thompson; J A Waterhouse
Journal: Am J Med Date: 1967-06 Impact factor: 4.965

5. Lymphoreticular dysfunction in idiopathic steatorrhoea.

Authors: C F McCarthy; I D Fraser; K T Evans; A E Read
Journal: Gut Date: 1966-04 Impact factor: 23.059

6. Studies of intestinal lymphoid tissue. I. Electron microscopic evidence of 'blast transformation' in epithelial lymphocytes of mouse small intestinal mucosa.

Authors: M N Marsh
Journal: Gut Date: 1975-09 Impact factor: 23.059

7. Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformis.

Authors: M Lancaster-Smith; P Kumar; R Marks; M L Clark; A M Dawson
Journal: Gut Date: 1974-05 Impact factor: 23.059

8. Steatorrhea and malignant lymphoma. The relationship of malignant tumors of lymphoid tissue and celiac disease.

Authors: W I Austad; J S Cornes; K R Gough; C F McCarthy; A E Read
Journal: Am J Dig Dis Date: 1967-05

9. Quantitation of intraepithelial lymphocytes in human jejunum.

Authors: A Ferguson; D Murray
Journal: Gut Date: 1971-12 Impact factor: 23.059

10. Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease.

Authors: B P Maclaurin; W T Cooke; N R Ling
Journal: Gut Date: 1971-10 Impact factor: 23.059

11 in total

1. Phenotyping of peripheral blood lymphocytes in adult coeliac disease.

Authors: A Di Sabatino; E Bertrandi; M Casadei Maldini; F Pennese; F Proietti; G R Corazza
Journal: Immunology Date: 1998-12 Impact factor: 7.397

2. DNA-synthesizing cells in the blood in coeliac disease and inflammatory bowel disease.

Authors: G K Holmes; P M Bratt; N R Ling; W T Cooke
Journal: Clin Exp Immunol Date: 1977-06 Impact factor: 4.330

3. Lymphocyte subpopulations in adult coeliac disease.

Authors: A W Bullen; M S Losowsky
Journal: Gut Date: 1978-10 Impact factor: 23.059

Review 4. Intraepithelial lymphocytes of the small intestine.

Authors: A Ferguson
Journal: Gut Date: 1977-11 Impact factor: 23.059

5. Increased concanavalin A induced suppression in treated and untreated coeliac disease.

Authors: C O'Farrelly; U McKeever; C Feighery; D G Weir
Journal: Gut Date: 1984-06 Impact factor: 23.059

6. Primary intestinal lymphomas.

Authors: H F Otto; I Bettmann; J V Weltzien; J O Gebbers
Journal: Virchows Arch A Pathol Anat Histol Date: 1981

7. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease.

Authors: A Di Sabatino; S D'Alò; D Millimaggi; R Ciccocioppo; R Parroni; G Sciarra; M G Cifone; G R Corazza
Journal: Immunology Date: 2001-08 Impact factor: 7.397

8. Lymphadenopathy in coeliac disease.

Authors: J P Simmonds; F D Rosenthal
Journal: Gut Date: 1981-09 Impact factor: 23.059

9. Cellular immunity in children with coeliac disease.

Authors: A Ashkenazi; S Levin; D Idar; Z T Handzel; Y Altman; A Or; N Barzilai
Journal: Eur J Pediatr Date: 1982-05 Impact factor: 3.183

Review 10. [Gluten-sensitive enteropathy--in the light of new clinical and pathogenetic aspects].

Authors: F Kluge; H K Koch; E Köttgen; W Gerok
Journal: Klin Wochenschr Date: 1983-07-15