Literature DB >> 10841497

En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B.

M D Chappell1, S J Stachel, C B Lee, S J Danishefsky.   

Abstract

[reaction--see text] Efficient and processable syntheses of key building blocks of the antitumor agent 12,13-desoxyepothilone B (dEpoB) by catalytic asymmetric induction are herein described.

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Year:  2000        PMID： 10841497     DOI： 10.1021/ol0059302

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  1 in total

1.  The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice.

Authors:  T C Chou; O A O'Connor; W P Tong; Y Guan; Z G Zhang; S J Stachel; C Lee; S J Danishefsky
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205
  1 in total

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