Literature DB >> 10840958

Oxepinamides A-C and fumiquinazolines H--I: bioactive metabolites from a marine isolate of a fungus of the genus Acremonium.

G N Belofsky1, M Anguera, P R Jensen, W Fenical, M Köck.   

Abstract

Three new oxepin-containing natural products (1-3) and two new fumiquinazoline metabolites (4-5) have been isolated from organic extracts of the culture broth and mycelia of an Acremonium sp., a fungus obtained from the surface of the Caribbean tunicate Ecteinascidia turbinata. The structures of the five compounds were determined through extensive analysis of 1D- and 2D-NMR data, and mass spectrometry. Compound 1 exhibited good anti-inflammatory activity in a topical RTX-induced mouse ear edema assay. Compounds 4 and 5 exhibited weak antifungal activity toward Candida albicans in a broth microdilution assay.

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Year:  2000        PMID： 10840958     DOI： 10.1002/(sici)1521-3765(20000417)6:8<1355::aid-chem1355>3.0.co;2-s

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  17 in total

Review 1.  Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Mark T Hamann
Journal:  Mar Biotechnol (NY)       Date:  2003-11-03       Impact factor: 3.619

2.  Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.

Authors:  Fang Yun Lim; Brian Ames; Christopher T Walsh; Nancy P Keller
Journal:  Cell Microbiol       Date:  2014-04-15       Impact factor: 3.715

3.  Imaging mass spectrometry of a coral microbe interaction with fungi.

Authors:  Wilna J Moree; Jane Y Yang; Xiling Zhao; Wei-Ting Liu; Marystella Aparicio; Librada Atencio; Javier Ballesteros; Joel Sánchez; Ronnie G Gavilán; Marcelino Gutiérrez; Pieter C Dorrestein
Journal:  J Chem Ecol       Date:  2013-07-24       Impact factor: 2.626

4.  Highly N-methylated linear peptides produced by an atypical sponge-derived Acremonium sp.

Authors:  Claudia M Boot; Karen Tenney; Frederick A Valeriote; Phillip Crews
Journal:  J Nat Prod       Date:  2006-01       Impact factor: 4.050

5.  Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.

Authors:  Brian D Ames; Xinyu Liu; Christopher T Walsh
Journal:  Biochemistry       Date:  2010-09-08       Impact factor: 3.162

6.  Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.

Authors:  Brian D Ames; Stuart W Haynes; Xue Gao; Bradley S Evans; Neil L Kelleher; Yi Tang; Christopher T Walsh
Journal:  Biochemistry       Date:  2011-09-19       Impact factor: 3.162

7.  Secondary metabolite arsenal of an opportunistic pathogenic fungus.

Authors:  Elaine Bignell; Timothy C Cairns; Kurt Throckmorton; William C Nierman; Nancy P Keller
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-05       Impact factor: 6.237

8.  Assessment of the Cytotoxic and Apoptotic Eἀects of Chaetominine in a Human Leukemia Cell Line.

Authors:  Jingyun Yao; Ruihua Jiao; Changqing Liu; Yupeng Zhang; Wanguo Yu; Yanhua Lu; Renxiang Tan
Journal:  Biomol Ther (Seoul)       Date:  2016-03-01       Impact factor: 4.634

Review 9.  The Oxepane Motif in Marine Drugs.

Authors:  Héctor Barbero; Carlos Díez-Poza; Asunción Barbero
Journal:  Mar Drugs       Date:  2017-11-15       Impact factor: 5.118

10.  A tropical marine microbial natural products geobibliography as an example of desktop exploration of current research using web visualisation tools.

Authors:  Joydeep Mukherjee; Lyndon E Llewellyn; Elizabeth A Evans-Illidge
Journal:  Mar Drugs       Date:  2008-10-13       Impact factor: 5.118
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