Literature DB >> 10840056

Opiates inhibit neurogenesis in the adult rat hippocampus.

A J Eisch1, M Barrot, C A Schad, D W Self, E J Nestler.   

Abstract

Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal function, we examined opiate regulation of neurogenesis in this brain region. Chronic administration of morphine decreased neurogenesis by 42% in the adult rat hippocampal granule cell layer. A similar effect was seen in rats after chronic self-administration of heroin. Opiate regulation of neurogenesis was not mediated by changes in circulating levels of glucocorticoids, because similar effects were seen in rats that received adrenalectomy and corticosterone replacement. These findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.

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Year:  2000        PMID： 10840056      PMCID： PMC16588          DOI： 10.1073/pnas.120552597

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  53 in total

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Review 5.  Effects of opioids on the hypothalamo-pituitary-adrenal axis.

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Journal:  Nat Neurosci       Date:  1999-03       Impact factor: 24.884

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  191 in total

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9.  Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats.

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10.  Neonatal morphine administration leads to changes in hippocampal BDNF levels and antioxidant enzyme activity in the adult life of rats.

Authors:  J R Rozisky; G Laste; I C de Macedo; V S Santos; R Krolow; C Noschang; C Vanzella; K Bertoldi; G A Lovatel; I C C de Souza; I R Siqueira; C Dalmaz; W Caumo; I L S Torres
Journal:  Neurochem Res       Date:  2012-12-09       Impact factor: 3.996
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