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Literature DB >> 10839471

Fluvastatin increases prostacyclin and decreases endothelin production by human umbilical vein endothelial cells.

Abstract

Fluvastatin, an agent of a class of lipid-lowering drugs, the "statins", significantly enhanced prostacyclin synthesis at the concentrations of 0.1 microM and 1 microM and significantly reduced endothelin production at the concentrations 0.01, 0.1 and 1 microM in cell cultures of human umbilical endothelial veins. Since prostacyclin is a vasodilator and endothelin a vasoconstrictor, fluvastatin may have a significant effect on hemodynamics by favoring the balance towards vasodilation. This mechanism may contribute to the prevention of cardiovascular diseases.

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Year: 2000 PMID： 10839471 DOI： 10.5414/cpp38270

Source DB: PubMed Journal: Int J Clin Pharmacol Ther ISSN： 0946-1965 Impact factor: 1.366

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Cited

11 in total

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10. Protective Effect of Statins on Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease Patients: A Nationwide Retrospective, Matched Cohort Study.

Authors: Wen-Ting Wu; Chung-Yu Chen
Journal: Sci Rep Date: 2020-02-20 Impact factor: 4.379

Fluvastatin increases prostacyclin and decreases endothelin production by human umbilical vein endothelial cells.

Review 1. Radiation as a risk factor for cardiovascular disease.

2. Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism.

Review 3. Potential therapeutic role for statins in respiratory disease.

Review 4. Anti-inflammatory and immunomodulating properties of statins. An additional tool for the therapeutic approach of systemic autoimmune diseases?

5. Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide.

6. A systematic review and meta-analysis of trials using statins in pulmonary arterial hypertension.

Review 7. Update on statin-mediated anti-inflammatory activities in atherosclerosis.

8. Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A.

Review 9. Statins and blood pressure: is there an effect or not?

10. Protective Effect of Statins on Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease Patients: A Nationwide Retrospective, Matched Cohort Study.