Literature DB >> 10838064

Differential preservation of cognitive functions in geriatric patients with lifelong chronic schizophrenia: less impairment in reading compared with other skill areas.

P D Harvey1, P J Moriarty, J I Friedman, L White, M Parrella, R C Mohs, K L Davis.   

Abstract

BACKGROUND: Our study examined the differential performance of cognitive skills in geriatric, cognitively impaired schizophrenic patients (n = 165) with a lengthy course of institutional stay and a poor overall functional outcome. Their relative deficits were compared with a sample of healthy elderly individuals.
METHODS: Schizophrenic patients were matched one-to-one with healthy individuals of the same age and education and compared on a number of measures of cognitive functioning. The schizophrenic patients' old-learning performance was also compared with their educational level only.
RESULTS: Mini-Mental State Examination (Folstein et al 1975) scores of the patients were in the moderately demented range (M = 20.36), and these patients underperformed healthy control subjects by more than 1 to slightly less than 3 standard deviations on measures of memory, praxis, and verbal skills. Wide Range Achievement Test-Revised word-recognition reading scores were found to be at the 10th-grade level, although the patients on average had completed 11 years of formal education.
CONCLUSIONS: These results suggest that even in schizophrenic patients with significant cognitive impairment, reading scores are relatively consistent with educational attainment. These data indicate that poor performance on measures of cognitive functioning in this population does not necessarily occur on measures of old learning.

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Year:  2000        PMID: 10838064     DOI: 10.1016/s0006-3223(00)00245-6

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN: 0006-3223            Impact factor:   13.382


  13 in total

Review 1.  Functional impairment in people with schizophrenia: focus on employability and eligibility for disability compensation.

Authors:  Philip D Harvey; Robert K Heaton; William T Carpenter; Michael F Green; James M Gold; Michael Schoenbaum
Journal:  Schizophr Res       Date:  2012-04-13       Impact factor: 4.939

Review 2.  Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models.

Authors:  L Lyon; L M Saksida; T J Bussey
Journal:  Psychopharmacology (Berl)       Date:  2011-11-10       Impact factor: 4.530

Review 3.  Very poor outcome schizophrenia: clinical and neuroimaging aspects.

Authors:  Serge A Mitelman; Monte S Buchsbaum
Journal:  Int Rev Psychiatry       Date:  2007-08

4.  The course of neuropsychological performance and functional capacity in older patients with schizophrenia: influences of previous history of long-term institutional stay.

Authors:  Philip D Harvey; Abraham Reichenberg; Christopher R Bowie; Thomas L Patterson; Robert K Heaton
Journal:  Biol Psychiatry       Date:  2010-03-03       Impact factor: 13.382

5.  Reading impairment and visual processing deficits in schizophrenia.

Authors:  Nadine Revheim; Pamela D Butler; Isaac Schechter; Maria Jalbrzikowski; Gail Silipo; Daniel C Javitt
Journal:  Schizophr Res       Date:  2006-08-04       Impact factor: 4.939

6.  Neuropsychological functioning in early and chronic stages of schizophrenia and psychotic bipolar disorder.

Authors:  Margo W Menkes; Kristan Armstrong; Jennifer Urbano Blackford; Stephan Heckers; Neil D Woodward
Journal:  Schizophr Res       Date:  2018-10-26       Impact factor: 4.939

7.  A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia.

Authors:  Mario Fioravanti; Olimpia Carlone; Barbara Vitale; Maria Elena Cinti; Linda Clare
Journal:  Neuropsychol Rev       Date:  2005-06       Impact factor: 7.444

8.  Right-hemisphere encephalopathy in elderly subjects with schizophrenia: evidence from neuropsychological and brain imaging studies.

Authors:  V S Gabrovska-Johnson; M Scott; S Jeffries; N Thacker; R C Baldwin; A Burns; S W Lewis; J F W Deakin
Journal:  Psychopharmacology (Berl)       Date:  2003-07-04       Impact factor: 4.530

9.  Reading deficits in schizophrenia and individuals at high clinical risk: relationship to sensory function, course of illness, and psychosocial outcome.

Authors:  Nadine Revheim; Cheryl M Corcoran; Elisa Dias; Esther Hellmann; Antigona Martinez; Pamela D Butler; Jonathan M Lehrfeld; Joanna DiCostanzo; Jennifer Albert; Daniel C Javitt
Journal:  Am J Psychiatry       Date:  2014-09       Impact factor: 18.112

Review 10.  Work, recovery, and comorbidity in schizophrenia: a randomized controlled trial of cognitive remediation.

Authors:  Susan R McGurk; Kim T Mueser; Thomas J DeRosa; Rosemarie Wolfe
Journal:  Schizophr Bull       Date:  2009-03-05       Impact factor: 9.306

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