Literature DB >> 10836742

Cytotoxic triterpenes from Crataegus pinnatifida.

B S Min1, Y H Kim, S M Lee, H J Jung, J S Lee, M K Na, C O Lee, J P Lee, K Bae.   

Abstract

Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.

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Year:  2000        PMID： 10836742     DOI： 10.1007/bf02975505

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  8 in total

1.  In Vitro Anti-cancer Effect of Crataegus oxyacantha Berry Extract on Hormone Receptor Positive and Triple Negative Breast Cancers via Regulation of Canonical Wnt Signaling Pathway.

Authors:  Salini Kombiyil; Niranjali Devaraj Sivasithamparam
Journal:  Appl Biochem Biotechnol       Date:  2022-03-09       Impact factor: 2.926

2.  Study on antibacterial effect of medlar and hawthorn compound extract in vitro.

Authors:  Yang Niu; Yi Nan; Ling Yuan; Rong Wang
Journal:  Afr J Tradit Complement Altern Med       Date:  2013-04-12

Review 3.  Effect of crataegus usage in cardiovascular disease prevention: an evidence-based approach.

Authors:  Jie Wang; Xingjiang Xiong; Bo Feng
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-29       Impact factor: 2.629

Review 4.  Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents.

Authors:  Codruţa Şoica; Mirela Voicu; Roxana Ghiulai; Cristina Dehelean; Roxana Racoviceanu; Cristina Trandafirescu; Oana-Janina Roșca; Gabriela Nistor; Marius Mioc; Alexandra Mioc
Journal:  Front Endocrinol (Lausanne)       Date:  2021-01-21       Impact factor: 5.555

5.  Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.

Authors:  Shuai Wang; Xin-Xin Yang; Tian-Jiao Li; Lin Zhao; Yong-Rui Bao; Xian-Sheng Meng
Journal:  Front Pharmacol       Date:  2022-08-30       Impact factor: 5.988

6.  Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells.

Authors:  Shengjie Yang; Qi Zhao; Hongmei Xiang; Minjie Liu; Qiuyun Zhang; Wei Xue; Baoan Song; Song Yang
Journal:  Cancer Cell Int       Date:  2013-02-09       Impact factor: 5.722

7.  Secondary metabolites from the roots of Beilschmiedia tsangii and their anti-inflammatory activities.

Authors:  Yun-Ting Huang; Hsun-Shuo Chang; Guei-Jane Wang; Chu-Hung Lin; Ih-Sheng Chen
Journal:  Int J Mol Sci       Date:  2012-12-03       Impact factor: 5.923

Review 8.  Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid.

Authors:  Juhyeon Son; Sang Yeol Lee
Journal:  Biomolecules       Date:  2020-11-02
  8 in total

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