Literature DB >> 10836065

Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.

P A Wender1, R Jeon.   

Abstract

[formula: see text] 4'-Bromoacetophenone derivatives which upon excitation can generate monophenyl radicals capable of hydrogen atom abstraction were investigated as photoinducible DNA cleaving agents. Pyrrolecarboxamide-conjugated 4'-bromoacetophenones were synthesized, and their DNA cleaving activities and sequence selectivities were determined.

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Year:  1999        PMID： 10836065     DOI： 10.1021/ol9903279

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Gas-phase reactivity of protonated 2-, 3-, and 4-dehydropyridine radicals toward organic reagents.

Authors:  Anthony Adeuya; Jason M Price; Bartłomiej J Jankiewicz; John J Nash; Hilkka I Kenttämaa
Journal:  J Phys Chem A       Date:  2009-12-10       Impact factor: 2.781

Review 2.  Properties and reactivity of gaseous distonic radical ions with aryl radical sites.

Authors:  Peggy E Williams; Bartłomiej J Jankiewicz; Linan Yang; Hilkka I Kenttämaa
Journal:  Chem Rev       Date:  2013-08-29       Impact factor: 60.622

3.  Correlation of hydrogen-atom abstraction reaction efficiencies for aryl radicals with their vertical electron affinities and the vertical ionization energies of the hydrogen-atom donors.

Authors:  Linhong Jing; John J Nash; Hilkka I Kenttämaa
Journal:  J Am Chem Soc       Date:  2008-12-31       Impact factor: 15.419
  3 in total

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