| Literature DB >> 10836047 |
W Han1, J C Pelletier, L J Mersinger, C A Kettner, C N Hodge.
Abstract
[formula: see text] The synthesis of thrombin inhibitor 3, which incorporates conformationally constrained 7-azabicycloheptane carboxylic acid (1) as a proline replacement, is described. The inhibition constant (Ki(thrombin) = 2.9 nM) indicates that 1 is a reasonable replacement of proline in the formation of a beta-turn tripeptide mimetic.Entities:
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Year: 1999 PMID： 10836047 DOI： 10.1021/ol990294x
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005