| Literature DB >> 10835685 |
M van Egmond1, E van Garderen, A B van Spriel, C A Damen, E S van Amersfoort, G van Zandbergen, J van Hattum, J Kuiper, J G van de Winkel.
Abstract
Despite the well-recognized involvement of immunoglobulin (Ig) A in mucosal immunity, the function of its receptor, FcalphaRI (CD89), is poorly understood. The ability of FcalphaRI to activate leukocytes seems to conflict with the proposed anti-inflammatory activity of secretory IgA. We show here that in a transgenic mouse model, inflammatory mediators induced expression of FcalphaRI on Kupffer cells, which enabled efficient phagocytosis in vivo of bacteria coated with serum IgA. Secretory IgA did not initiate phagocytosis. Therefore, interactions between serum IgA and FcalphaRI on Kupffer cells may provide a 'second line of defense' in mucosal immunity, by eliminating invasive bacteria entering through the portal circulation and thus preventing disease.Entities:
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Year: 2000 PMID： 10835685 DOI： 10.1038/76261
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440