Literature DB >> 10835603

Surface-displayed viral antigens on Salmonella carrier vaccine.

J S Lee1, K S Shin, J G Pan, C J Kim.   

Abstract

We have developed a recombinant live oral vaccine using the ice-nucleation protein (Inp) from Pseudomonas syringae to display viral antigens on the surface of Salmonella spp. Fusion proteins containing viral antigens were expressed in the oral vaccine strain, Salmonella typhi Ty21a. Surface localization was verified by immunoblotting and fluorescence-activated cell sorting. The immunogenicity of surface-displayed viral antigens on the recombinant live vaccine strain was assessed in mice inoculated intranasally and intraperitoneally. Inoculation resulted in significantly higher serum antibody level than those induced by viral antigens expressed intracellularly. Thus, this multivalent mucosal live vaccine may provide an effective means for inducing mucosal or systemic immune responses against multiple viral antigens.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10835603     DOI： 10.1038/76494

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  46 in total

1.  Surface display of domain III of Japanese encephalitis virus E protein on Salmonella typhimurium by using an ice nucleation protein.

Authors:  Jian-Lin Dou; Tao Jing; Jing-Jing Fan; Zhi-Ming Yuan
Journal:  Virol Sin       Date:  2011-12-10       Impact factor: 4.327

2.  Evaluation of oral immunization with recombinant avian influenza virus HA1 displayed on the Lactococcus lactis surface and combined with the mucosal adjuvant cholera toxin subunit B.

Authors:  Han Lei; Zhina Sheng; Qian Ding; Jian Chen; Xiaohui Wei; Dominic Man-Kit Lam; Yuhong Xu
Journal:  Clin Vaccine Immunol       Date:  2011-06-01

Review 3.  Enteric pathogens as vaccine vectors for foreign antigen delivery.

Authors:  Camille N Kotton; Elizabeth L Hohmann
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

4.  Retrospective analysis of a local cessation of vaccination against poliomyelitis: a possible scenario for the future.

Authors:  Ekaterina A Korotkova; Renee Park; Elena A Cherkasova; Galina Y Lipskaya; Konstantin M Chumakov; Esfir V Feldman; Olen M Kew; Vadim I Agol
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

Review 5.  Developments in high-yield system expressed vaccines and immunotherapy.

Authors:  Marissa Geels; Kaiming Ye
Journal:  Recent Pat Biotechnol       Date:  2010-11

6.  Cell-surface expression of Aspergillus saitoi-derived functional α-1,2-mannosidase on Yarrowia lipolytica for glycan remodeling.

Authors:  Hye Yun Moon; Trinh Luu Van; Seon Ah Cheon; Jinho Choo; Jeong-Yoon Kim; Hyun Ah Kang
Journal:  J Microbiol       Date:  2013-08-30       Impact factor: 3.422

7.  Efficient and stable display of functional proteins on bacterial magnetic particles using mms13 as a novel anchor molecule.

Authors:  Tomoko Yoshino; Tadashi Matsunaga
Journal:  Appl Environ Microbiol       Date:  2006-01       Impact factor: 4.792

8.  Translocation of green fluorescent protein to cyanobacterial periplasm using ice nucleation protein.

Authors:  Wipa Chungjatupornchai; Sirirat Fa-aroonsawat
Journal:  J Microbiol       Date:  2009-05-02       Impact factor: 3.422

9.  Development of a cell surface display system in a magnetotactic bacterium, "Magnetospirillum magneticum" AMB-1.

Authors:  Masayoshi Tanaka; Yuko Nakata; Tetsushi Mori; Yoshiko Okamura; Hitoshi Miyasaka; Haruko Takeyama; Tadashi Matsunaga
Journal:  Appl Environ Microbiol       Date:  2008-03-31       Impact factor: 4.792

10.  Induction of immune responses in mice after oral immunization with recombinant Lactobacillus casei strains expressing enterotoxigenic Escherichia coli F41 fimbrial protein.

Authors:  Jian-Kui Liu; Xi-Lin Hou; Chun-Hua Wei; Li-Yun Yu; Xiao-Jie He; Gui-Hua Wang; Jong-Soo Lee; Chul-Joong Kim
Journal:  Appl Environ Microbiol       Date:  2009-05-15       Impact factor: 4.792
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.