Literature DB >> 10835488

Isolation of two novel genes, down-regulated in gastric cancer.

Y Yoshikawa1, H Mukai, F Hino, K Asada, I Kato.   

Abstract

Using a differential display technique, we identified two genes that are down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. The down-regulated expression of these genes in gastric cancer tissue was confirmed by northern blotting analysis and RT-PCR. One, CA11, was a novel gene expressed predominantly in the stomach and was depleted in all of the gastric cancer cell lines examined. The other gene, GC36, was homologous to the digestive tract-specific calpain gene, nCL-4. The expression of both GC36 and nCL-4 was suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types. This is the first report of genes, the expression of which is down-regulated with considerable frequency in gastric cancer.

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Year:  2000        PMID： 10835488      PMCID： PMC5926377          DOI： 10.1111/j.1349-7006.2000.tb00967.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


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