A B Dessens1, H S Haas, J G Koppe. 1. Academic Medical Center, University of Amsterdam, Department of Neonatology, Amsterdam, The Netherlands. arides@delta-pz.nl
Abstract
OBJECTIVE: To study late side effects of antenatal corticosteroid treatment on health and sexual development in subjects 20 to 22 years old. METHODS: A follow-up study among young adults whose mothers had, because of a threatening delivery, participated in a randomized, double-blind, placebo- controlled trial of betamethasone to prevent neonatal respiratory distress syndrome. Measurements were taken on general health, growth, development in puberty, reproductivity, genital or gynecological complaints, gender development, sexual orientation, sex-specific cognitive functioning, and psychoneuroticism. In addition, some measurements were performed on family diseases, socioeconomic status, and education. RESULTS: No differences were found between the corticosteroid-treated and placebo groups as to medical or psychological variables. In general, the subjects were healthy and had normal intellectual capacities. Groups did not differ on gender development, sexual orientation, sex-specific cognitive functioning, and psychoneuroticism. Systolic blood pressure was significantly lower in the corticosteroid group, but the groups did not differ as to diastolic blood pressure. CONCLUSIONS: Our 20-year follow-up study indicates that 1 course of antenatally administered corticosteroid to prevent respiratory distress syndrome does not have adverse effects up to adulthood.
RCT Entities:
OBJECTIVE: To study late side effects of antenatal corticosteroid treatment on health and sexual development in subjects 20 to 22 years old. METHODS: A follow-up study among young adults whose mothers had, because of a threatening delivery, participated in a randomized, double-blind, placebo- controlled trial of betamethasone to prevent neonatal respiratory distress syndrome. Measurements were taken on general health, growth, development in puberty, reproductivity, genital or gynecological complaints, gender development, sexual orientation, sex-specific cognitive functioning, and psychoneuroticism. In addition, some measurements were performed on family diseases, socioeconomic status, and education. RESULTS: No differences were found between the corticosteroid-treated and placebo groups as to medical or psychological variables. In general, the subjects were healthy and had normal intellectual capacities. Groups did not differ on gender development, sexual orientation, sex-specific cognitive functioning, and psychoneuroticism. Systolic blood pressure was significantly lower in the corticosteroid group, but the groups did not differ as to diastolic blood pressure. CONCLUSIONS: Our 20-year follow-up study indicates that 1 course of antenatally administered corticosteroid to prevent respiratory distress syndrome does not have adverse effects up to adulthood.
Authors: Andrew M South; Patricia A Nixon; Mark C Chappell; Debra I Diz; Gregory B Russell; Beverly M Snively; Hossam A Shaltout; James C Rose; T Michael O'Shea; Lisa K Washburn Journal: Pediatr Res Date: 2016-09-16 Impact factor: 3.756
Authors: Martijn J J Finken; Bibian van der Voorn; Jonneke J Hollanders; Charlotte A Ruys; Marita de Waard; Johannes B van Goudoever; Joost Rotteveel Journal: Ann Nutr Metab Date: 2017-03-17 Impact factor: 3.374
Authors: Praveen Kumar; Scott A Venners; Lingling Fu; Colleen Pearson; Katherin Ortiz; Xiaobin Wang Journal: Early Hum Dev Date: 2011-05-14 Impact factor: 2.079
Authors: Stuart R Dalziel; Vanessa K Lim; Anthony Lambert; Dianne McCarthy; Varsha Parag; Anthony Rodgers; Jane E Harding Journal: BMJ Date: 2005-09-05
Authors: Lynda J Stinson; Laura R Stroud; Stephen L Buka; Charles B Eaton; Bing Lu; Raymond Niaura; Eric B Loucks Journal: Psychosom Med Date: 2015-04 Impact factor: 4.312