Literature DB >> 10834565

Estimates of genetic parameters for hip and elbow dysplasia in Finnish Rottweilers.

K Mäki1, A E Liinamo, M Ojala.   

Abstract

Data from 2,764 Rottweiler dogs born from 1987 to 1996 were analyzed with a Restricted Maximum Likelihood procedure using a mixed linear animal model to obtain variance component estimates for hip and elbow dysplasia. The data included 2,764 hip dysplasia and 2,278 elbow dysplasia records. Hip joints were scored as normal (0), borderline (1), slight (2), moderate (3), and severe (4, 4.5, and 5) hip dysplasia. Elbow joints were graded normal or borderline (0), slight (1), moderate (2), and severe (3) elbow dysplasia. The mean for the hip scores was 1.07 and for the elbow scores .60. Environmental effects influencing hip dysplasia were age, birth year, birth year x season interaction, and experience of the veterinarian responsible for x-raying the dog. For elbow dysplasia, statistically significant effects were age, birth year, sex of the dog, and panelist responsible for each screening. Estimates of heritability for hip and elbow dysplasia were .58 +/- .04 and .31 +/- .04, respectively, with a genetic correlation of .37 +/- .08 between the traits. Genetic improvement of almost one genetic standard deviation was observed in both traits during the 10 yr covered by the data.

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Year:  2000        PMID: 10834565     DOI: 10.2527/2000.7851141x

Source DB:  PubMed          Journal:  J Anim Sci        ISSN: 0021-8812            Impact factor:   3.159


  7 in total

Review 1.  The long (and winding) road to gene discovery for canine hip dysplasia.

Authors:  Lan Zhu; Zhiwu Zhang; Steven Friedenberg; Seung-Woo Jung; Janjira Phavaphutanon; Margaret Vernier-Singer; Elizabeth Corey; Raluca Mateescu; Nathan Dykes; Jody Sandler; Gregory Acland; George Lust; Rory Todhunter
Journal:  Vet J       Date:  2009-03-17       Impact factor: 2.688

2.  Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA.

Authors:  Yali Hou; Yachun Wang; Xuemei Lu; Xu Zhang; Qian Zhao; Rory J Todhunter; Zhiwu Zhang
Journal:  PLoS One       Date:  2013-10-04       Impact factor: 3.240

3.  Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds.

Authors:  A M Oberbauer; G G Keller; T R Famula
Journal:  PLoS One       Date:  2017-02-24       Impact factor: 3.240

4.  Genetic improvement of hip-extended scores in 3 breeds of guide dogs using estimated breeding values: Notable progress but more improvement is needed.

Authors:  Eldin A Leighton; Dolores Holle; Darryl N Biery; Thomas P Gregor; Mischa B McDonald-Lynch; Mandy L Wallace; Jennifer K Reagan; Gail K Smith
Journal:  PLoS One       Date:  2019-02-22       Impact factor: 3.240

5.  Prevalence of Canine Hip Dysplasia in Switzerland Between 1995 and 2016-A Retrospective Study in 5 Common Large Breeds.

Authors:  Stefanie Ohlerth; Britta Geiser; Mark Flückiger; Urs Geissbühler
Journal:  Front Vet Sci       Date:  2019-10-24

6.  Estimate of heritability and genetic trend of intervertebral disc calcification in Dachshunds in Finland.

Authors:  Anu Katriina Lappalainen; Katariina Mäki; Outi Laitinen-Vapaavuori
Journal:  Acta Vet Scand       Date:  2015-11-23       Impact factor: 1.695

Review 7.  Emerging insights into the genetic basis of canine hip dysplasia.

Authors:  Mário Ginja; Ana Rita Gaspar; Catarina Ginja
Journal:  Vet Med (Auckl)       Date:  2015-05-20
  7 in total

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