| Literature DB >> 10834273 |
I Niculescu-Duvaz1, F Friedlos, D Niculescu-Duvaz, L Davies, C J Springer.
Abstract
Antibody- and gene-directed enzyme prodrug therapy are two-step targeting strategies designed to improve the selectivity of antitumour agents. The approaches are based on the activation of specially designed prodrugs by antibody-enzyme conjugates targeted to tumour-associated antigens (ADEPT) or by enzymes expressed by exogenous genes in tumour cells (GDEPT). Herein the design, synthesis, physico-chemical and biological properties, kinetics and clinical trials of the prodrugs and the enzymes carboxypeptidase G2 and nitroreductase are reviewed for ADEPT and GDEPT.Entities:
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Year: 1999 PMID： 10834273
Source DB: PubMed Journal: Anticancer Drug Des ISSN： 0266-9536