BACKGROUND: Warfarin is associated with numerous drug and food interactions, and much attention has been appropriately focused on this subject. Because several disease states may also affect response to oral anticoagulants, we present a summary of the literature. METHODS: We searched MEDLINE for original articles on the effect of disease states on response to warfarin. RESULTS: Liver disease and thyroid dysfunction are well-documented as affecting warfarin response. Further study is needed to establish whether febrile illness, congestive heart failure, and other disease states enhance the effect of warfarin in some patients. CONCLUSION: Careful monitoring of anticoagulant therapy in patients with diseases that have the potential to affect warfarin response could increase safety and efficacy of this important agent.
BACKGROUND:Warfarin is associated with numerous drug and food interactions, and much attention has been appropriately focused on this subject. Because several disease states may also affect response to oral anticoagulants, we present a summary of the literature. METHODS: We searched MEDLINE for original articles on the effect of disease states on response to warfarin. RESULTS:Liver disease and thyroid dysfunction are well-documented as affecting warfarin response. Further study is needed to establish whether febrile illness, congestive heart failure, and other disease states enhance the effect of warfarin in some patients. CONCLUSION: Careful monitoring of anticoagulant therapy in patients with diseases that have the potential to affect warfarin response could increase safety and efficacy of this important agent.
Authors: Talitha I Verhoef; William K Redekop; Ann K Daly; Rianne M F van Schie; Anthonius de Boer; Anke-Hilse Maitland-van der Zee Journal: Br J Clin Pharmacol Date: 2014-04 Impact factor: 4.335
Authors: Tom Schalekamp; Johanna H H van Geest-Daalderop; Mark H H Kramer; Angelique T M van Holten-Verzantvoort; Anthonius de Boer Journal: Eur J Clin Pharmacol Date: 2007-02-21 Impact factor: 2.953
Authors: Jung Nam An; Shin Young Ahn; Chang-Hwan Yoon; Tae-Jin Youn; Moon-Ku Han; Sejoong Kim; Ho Jun Chin; Ki Young Na; Dong-Wan Chae Journal: PLoS One Date: 2013-04-01 Impact factor: 3.240