T V McCaffrey1. 1. Department of Otolaryngology Head and Neck Surgery, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA.
Abstract
BACKGROUND: Clinically detectable thyroid nodules occur in up to 4% of the population in the United States. With ultrasound, nodules may be found in up to 50% of those over 50 years of age. METHODS: The author reviews his own experience as well as that of others to define a sound clinical approach to the differential diagnosis and detection of thyroid cancer. RESULTS: Prior neck irradiation is a risk factor for thyroid malignancy. The association of a thyroid nodule with enlarged lymph nodes or fixation of the nodule to strap muscles or the trachea suggests malignancy. A diffusely multinodular gland is usually benign. CONCLUSIONS: Thyroid function tests rarely help a differential diagnosis. Fine-needle aspiration is the "gold standard" for diagnosis. Tiny "incidentalomas" are often followed with repeat monitoring for change of size or character.
BACKGROUND: Clinically detectable thyroid nodules occur in up to 4% of the population in the United States. With ultrasound, nodules may be found in up to 50% of those over 50 years of age. METHODS: The author reviews his own experience as well as that of others to define a sound clinical approach to the differential diagnosis and detection of thyroid cancer. RESULTS: Prior neck irradiation is a risk factor for thyroid malignancy. The association of a thyroid nodule with enlarged lymph nodes or fixation of the nodule to strap muscles or the trachea suggests malignancy. A diffusely multinodular gland is usually benign. CONCLUSIONS: Thyroid function tests rarely help a differential diagnosis. Fine-needle aspiration is the "gold standard" for diagnosis. Tiny "incidentalomas" are often followed with repeat monitoring for change of size or character.
Authors: Marcos A Soares de Oliveira; Michael Campbell; Alaa M Afify; Eric C Huang; James W Chan Journal: J Biomed Opt Date: 2022-09 Impact factor: 3.758