Literature DB >> 10832008

Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells.

X Q Xiao1, R Wang, Y F Han, X C Tang.   

Abstract

The effects of huperzine A (HupA), a novel acetylcholinesterase inhibitor, on Abeta(25-35)-induced cell lesion, level of lipid peroxidation, antioxidant enzyme activities were investigated in the rat pheochromocytoma line PC12. Following a 48 h exposure of the cells to Abeta(25-35), a significant reduction in cell survival and activities of glutathione peroxidase (GSH-Px) and catalase (CAT), as well as increased production of malondialdehyde (MDA) and superoxide dismutase (SOD) were observed. Preincubation of the cells with HupA prior to Abeta(25-35) exposure elevated the cell survival and GSH-Px and CAT activities, and decreased the level of MDA and SOD activity. The results indicate that HupA has protective effects against Abeta-induced cell toxicity, which might be beneficial for the treatment of Alzheimer's disease.

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Year:  2000        PMID： 10832008     DOI： 10.1016/s0304-3940(00)01088-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  16 in total

Review 1.  Neuroprotective effect of natural products against Alzheimer's disease.

Authors:  Musthafa M Essa; Reshmi K Vijayan; Gloria Castellano-Gonzalez; Mustaq A Memon; Nady Braidy; Gilles J Guillemin
Journal:  Neurochem Res       Date:  2012-05-22       Impact factor: 3.996

2.  Comparable attenuation of Abeta(25-35)-induced neurotoxicity by quercitrin and 17beta-estradiol in cultured rat hippocampal neurons.

Authors:  Sadudee Rattanajarasroj; Surachai Unchern
Journal:  Neurochem Res       Date:  2010-05-15       Impact factor: 3.996

Review 3.  Huperzine A for mild cognitive impairment.

Authors:  Jirong Yue; Bi Rong Dong; Xiufang Lin; Ming Yang; Hong Mei Wu; Taixiang Wu
Journal:  Cochrane Database Syst Rev       Date:  2012-12-12

4.  [+]-Huperzine A protects against soman toxicity in guinea pigs.

Authors:  Ying Wang; Yanling Wei; Samuel Oguntayo; Neil Jensen; Bhupendra P Doctor; Madhusoodana P Nambiar
Journal:  Neurochem Res       Date:  2011-08-07       Impact factor: 3.996

Review 5.  Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.

Authors:  Hai Yan Zhang; Han Yan; Xi Can Tang
Journal:  Cell Mol Neurobiol       Date:  2007-07-27       Impact factor: 5.046

6.  The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells.

Authors:  Jiao-Ning Shen; Deng-Shun Wang; Rui Wang
Journal:  Int J Clin Exp Pathol       Date:  2012-10-20

7.  New insights into huperzine A for the treatment of Alzheimer's disease.

Authors:  Hai-Yan Zhang
Journal:  Acta Pharmacol Sin       Date:  2012-09-03       Impact factor: 6.150

8.  Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.

Authors:  Yan Qi Liang; Xiao Tian Huang; Xi Can Tang
Journal:  Cell Mol Neurobiol       Date:  2007-07-17       Impact factor: 5.046

9.  Examining the interactome of huperzine A by magnetic biopanning.

Authors:  Wei Guo; Shupeng Liu; Jinliang Peng; Xiaohui Wei; Ye Sun; Yangsheng Qiu; Guangwei Gao; Peng Wang; Yuhong Xu
Journal:  PLoS One       Date:  2012-05-16       Impact factor: 3.240

Review 10.  Treating senile dementia with traditional Chinese medicine.

Authors:  Han Yan; Lin Li; Xi Can Tang
Journal:  Clin Interv Aging       Date:  2007       Impact factor: 4.458
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