T H Nguyen1, T Larsen, G Engholm, H Møller. 1. Department of Ultrasound, Herlev Hospital University of Copenhagen, Herlev, Denmark. trihuu@dadlnet.dk
Abstract
OBJECTIVE: To estimate the risk of adverse outcomes in women whose first day of the last menstrual period (LMP) was unreliable. METHODS: Among 20,244 singleton pregnancies with measurements of biparietal diameter between 12 and 22 weeks' gestation, LMP was registered as unreliable in 3775 (18.6%) and reliable in 16,469 (81.4%). Adverse outcomes were defined as spontaneous or missed abortions after 12 weeks' gestation, stillbirth or postnatal death within 1 year, preterm birth, birth weight less than 2500 g, and low birth weight (LBW) for gestation (lower than 22% below sex-specific expected weight). Logistic regression analysis and Kaplan-Meier survival analysis were used to analyze the risk of adverse outcomes. RESULTS: The risk of death was doubled in pregnant women with unreliable LMPs compared with those with reliable LMPs (odds ratio [OR] 2.0; 95% confidence interval [CI] 1.5, 2.6). This risk was highest with respect to stillbirth (OR 2.7; 95% CI 1.7, 4.3). The risks of preterm birth, LBW, and LBW for gestation were also significantly increased (ORs 1.5, 1.4, and 1.2; 95% CIs 1.3, 1.7; 1.2, 1.6; and 1. 0, 1.4, respectively). CONCLUSION: An unreliable LMP is associated with increased risk of adverse outcomes, especially fetal death.
OBJECTIVE: To estimate the risk of adverse outcomes in women whose first day of the last menstrual period (LMP) was unreliable. METHODS: Among 20,244 singleton pregnancies with measurements of biparietal diameter between 12 and 22 weeks' gestation, LMP was registered as unreliable in 3775 (18.6%) and reliable in 16,469 (81.4%). Adverse outcomes were defined as spontaneous or missed abortions after 12 weeks' gestation, stillbirth or postnatal death within 1 year, preterm birth, birth weight less than 2500 g, and low birth weight (LBW) for gestation (lower than 22% below sex-specific expected weight). Logistic regression analysis and Kaplan-Meier survival analysis were used to analyze the risk of adverse outcomes. RESULTS: The risk of death was doubled in pregnant women with unreliable LMPs compared with those with reliable LMPs (odds ratio [OR] 2.0; 95% confidence interval [CI] 1.5, 2.6). This risk was highest with respect to stillbirth (OR 2.7; 95% CI 1.7, 4.3). The risks of preterm birth, LBW, and LBW for gestation were also significantly increased (ORs 1.5, 1.4, and 1.2; 95% CIs 1.3, 1.7; 1.2, 1.6; and 1. 0, 1.4, respectively). CONCLUSION: An unreliable LMP is associated with increased risk of adverse outcomes, especially fetal death.
Authors: A T Papageorghiou; S H Kennedy; L J Salomon; E O Ohuma; L Cheikh Ismail; F C Barros; A Lambert; M Carvalho; Y A Jaffer; E Bertino; M G Gravett; D G Altman; M Purwar; J A Noble; R Pang; C G Victora; Z A Bhutta; J Villar Journal: Ultrasound Obstet Gynecol Date: 2014-11-02 Impact factor: 7.299
Authors: Zilma Silveira Nogueira Reis; Rodney Nascimento Guimarães; Maria Albertina Santiago Rego; Roberta Maia de Castro Romanelli; Juliano de Souza Gaspar; Gabriela Luiza Nogueira Vitral; Marconi Augusto Aguiar Dos Reis; Enrico Antônio Colósimo; Gabriela Silveira Neves; Marynea Silva Vale; Paulo de Jesus Hartamann Nader; Marta David Rocha de Moura; Regina Amélia Pessoa Lopes de Aguiar Journal: BMJ Open Date: 2019-03-05 Impact factor: 2.692
Authors: A T Papageorghiou; B Kemp; W Stones; E O Ohuma; S H Kennedy; M Purwar; L J Salomon; D G Altman; J A Noble; E Bertino; M G Gravett; R Pang; L Cheikh Ismail; F C Barros; A Lambert; Y A Jaffer; C G Victora; Z A Bhutta; J Villar Journal: Ultrasound Obstet Gynecol Date: 2016-12 Impact factor: 7.299