OBJECTIVE: The authors' goal was to determine whether sertraline attenuates the increased platelet activation seen among depressed patients. METHOD: They tested 21 otherwise healthy patients with untreated major depressive episode who were 25-52 years old and 21 age- and sex-matched comparison subjects. Patients received 6 weeks of sertraline treatment, and 17 returned for retesting. RESULTS: At baseline, the depressed patients had greater platelet secretion than the comparison subjects in response to collagen. Depressed patients with a family history of coronary disease had nonsignificantly greater wound-induced fibrinogen receptor binding than the other subjects. Platelet secretion in response to collagen was significantly reduced after treatment with sertraline. CONCLUSIONS: Sertraline diminished the increased platelet secretion found among depressed patients, although the findings are limited by a lack of a placebo control group.
OBJECTIVE: The authors' goal was to determine whether sertraline attenuates the increased platelet activation seen among depressedpatients. METHOD: They tested 21 otherwise healthy patients with untreated major depressive episode who were 25-52 years old and 21 age- and sex-matched comparison subjects. Patients received 6 weeks of sertraline treatment, and 17 returned for retesting. RESULTS: At baseline, the depressedpatients had greater platelet secretion than the comparison subjects in response to collagen. Depressedpatients with a family history of coronary disease had nonsignificantly greater wound-induced fibrinogen receptor binding than the other subjects. Platelet secretion in response to collagen was significantly reduced after treatment with sertraline. CONCLUSIONS:Sertraline diminished the increased platelet secretion found among depressedpatients, although the findings are limited by a lack of a placebo control group.
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Authors: Nunzio Pomara; P Murali Doraiswamy; Lisa M Willoughby; Amy E Roth; Benoit H Mulsant; John J Sidtis; Pankaj D Mehta; Charles F Reynolds; Bruce G Pollock Journal: Neurochem Res Date: 2006-04-01 Impact factor: 3.996
Authors: James A Blumenthal; Andrew Sherwood; Sharon D Rogers; Michael A Babyak; P Murali Doraiswamy; Lana Watkins; Benson M Hoffman; Cara O'Connell; Julie J Johnson; Seema M Patidar; Robert Waugh; Alan Hinderliter Journal: Clin Trials Date: 2007 Impact factor: 2.486