Literature DB >> 10827455

US gene therapy in crisis.

D Teichler Zallen1.   

Abstract

The recent death of a young man, Jesse Gelsinger, in a gene therapy experiment has sent shock waves throughout the US research community. This tragic event has raised new questions about the prospects for human gene therapy. And it has also reopened old controversies about how best to guide the development of this field.

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Year:  2000        PMID： 10827455     DOI： 10.1016/s0168-9525(00)02025-4

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  18 in total

1.  Development and characterization of novel empty adenovirus capsids and their impact on cellular gene expression.

Authors:  Jackie L Stilwell; Douglas M McCarty; Atsuko Negishi; Richard Superfine; R Jude Samulski
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

Review 2.  Cystic fibrosis: a brief look at some highlights of a decade of research focused on elucidating and correcting the molecular basis of the disease.

Authors:  Y H Ko; P L Pedersen
Journal:  J Bioenerg Biomembr       Date:  2001-12       Impact factor: 2.945

Review 3.  Intratympanic Gene Delivery of Antimicrobial Molecules in Otitis Media.

Authors:  Sung K Moon; David J Lim
Journal:  Curr Allergy Asthma Rep       Date:  2015-04       Impact factor: 4.806

4.  Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors.

Authors:  S Ren; M Nassal
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

Review 5.  Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013.

Authors:  Marina O'Reilly; Howard J Federoff; Yuman Fong; Donald B Kohn; Amy P Patterson; Nabil Ahmed; Aravind Asokan; Shannon E Boye; Ronald G Crystal; Satiro De Oliveira; Linda Gargiulo; Scott Q Harper; Yasuhiro Ikeda; Robert Jambou; Maureen Montgomery; Lawrence Prograis; Eugene Rosenthal; Daniel H Sterman; Luk H Vandenberghe; Laurie Zoloth; Mehrdad Abedi; Jennifer Adair; Prasad S Adusumilli; William F Goins; Jhanelle Gray; Paul Monahan; Leslie Popplewell; Miguel Sena-Esteves; Bakhos Tannous; Thomas Weber; William Wierda; Rashmi Gopal-Srivastava; Cheryl L McDonald; Daniel Rosenblum; Jacqueline Corrigan-Curay
Journal:  Hum Gene Ther       Date:  2014-06       Impact factor: 5.695

6.  Multiplexed supramolecular self-assembly for non-viral gene delivery.

Authors:  Nathan P Gabrielson; Jianjun Cheng
Journal:  Biomaterials       Date:  2010-09-01       Impact factor: 12.479

7.  Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair.

Authors:  Nadav Kimelman-Bleich; Gadi Pelled; Yoram Zilberman; Ilan Kallai; Olga Mizrahi; Wafa Tawackoli; Zulma Gazit; Dan Gazit
Journal:  Mol Ther       Date:  2010-09-21       Impact factor: 11.454

8.  BIOPHYSICS MEETS GENE THERAPY: HOW EXPLORING SUPERCOILING-DEPENDENT STRUCTURAL CHANGES IN DNA LED TO THE DEVELOPMENT OF MINIVECTOR DNA.

Authors:  Lynn Zechiedrich; Jonathan M Fogg
Journal:  Technol Innov       Date:  2019-08-01

9.  Genetic and phenotypic targeting of β-adrenergic signaling in heart failure.

Authors:  Walter J Koch
Journal:  Mol Cell Biochem       Date:  2004-08       Impact factor: 3.396

Review 10.  Gene therapy for cerebral vascular disease: update 2003.

Authors:  Kazunori Toyoda; Yi Chu; Donald D Heistad
Journal:  Br J Pharmacol       Date:  2003-05       Impact factor: 8.739
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