BACKGROUND: A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE: We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in middle-aged and elderly men. METHODS: Participants were 431 male members of the Health Professionals Follow-up Study who responded to a question in 1992 on their hair pattern at 45 years of age and who were 47 to 81 years old when they provided a blood specimen in 1993-1994. Odds ratios (ORs) of vertex balding associated with IGF-1 and IGFBP-3 were estimated from logistic regression models mutually adjusting for each other and controlling for age at blood draw. RESULTS: Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1. 31 (95% CI, 0.95-1.81). For a 1 standard deviation increase in plasma IGFBP-3 (957 ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88). CONCLUSION: Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
BACKGROUND: A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE: We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in middle-aged and elderly men. METHODS:Participants were 431 male members of the Health Professionals Follow-up Study who responded to a question in 1992 on their hair pattern at 45 years of age and who were 47 to 81 years old when they provided a blood specimen in 1993-1994. Odds ratios (ORs) of vertex balding associated with IGF-1 and IGFBP-3 were estimated from logistic regression models mutually adjusting for each other and controlling for age at blood draw. RESULTS: Of the 431 men, 128 had vertex balding at age 45. Compared with men who were not balding, for a 1 standard deviation increase in plasma IGF-1 level (72.4 ng/mL), the OR for vertex balding was 1. 31 (95% CI, 0.95-1.81). For a 1 standard deviation increase in plasma IGFBP-3 (957 ng/mL), the OR for vertex balding was 0.62 (95% CI, 0.44-0.88). CONCLUSION: Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
Authors: Jean-Alfred Thomas; Jodi A Antonelli; Lionel L Banez; Catherine Hoyo; Delores Grant; Wendy Demark-Wahnefried; Elizabeth A Platz; Leah Gerber; Kathryn Shuler; Enwono Eyoh; Elizabeth Calloway; Stephen J Freedland Journal: Cancer Causes Control Date: 2013-03-26 Impact factor: 2.506
Authors: Cindy Ke Zhou; Ruth M Pfeiffer; Sean D Cleary; Heather J Hoffman; Paul H Levine; Lisa W Chu; Ann W Hsing; Michael B Cook Journal: J Clin Oncol Date: 2014-09-15 Impact factor: 44.544
Authors: Ericka M Ebot; Lorelei A Mucci; Xiaoshuang Feng; Cindy Ke Zhou; Clary B Clish; Kathryn M Wilson; Claire H Pernar; Barbra A Dickerman; Massimo Loda; Stephen P Finn; Kathryn L Penney; Daniel R Schmidt; Matthew G Vander Heiden; Edward L Giovannucci Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-02-24 Impact factor: 4.090