Literature DB >> 1082723

Investigations on the influence of different corticosteroids on the development of galactose cataracts in rats.

H R Koch, H Eckert, H Wendt.   

Abstract

The influence of daily subcutaneous injections of 5 different corticosteroids (15 mg/kg body weight) on the development of galactose opacities in young rats of approximately 60g body weight was investigated. Progress of cataracts was evaluated by planimetry of lens photos. The three glucocorticosteroids used (cortisol, prednisolone, fluocortolone) induced a slight acceleration of cataract development, while a mineralocorticoid (desoxy-corticosterone) caused a marked retardation. A temporary retardation was also observed with fluocortinbutyl, a rapidly metabolized steroid for topical use.

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Year:  1976        PMID： 1082723     DOI： 10.1007/bf00410010

Source DB:  PubMed          Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol        ISSN： 0065-6100


  6 in total

1.  Examination of lenses of steroid-treated rats.

Authors:  L VON SALLMANN; L L CARAVAGGIO; E M COLLINS; K WEAVER
Journal:  Am J Ophthalmol       Date:  1960-12       Impact factor: 5.258

2.  Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis.

Authors:  R L BLACK; R B OGLESBY; L VON SALLMANN; J J BUNIM
Journal:  JAMA       Date:  1960-09-10       Impact factor: 56.272

3.  [Additional development of cataract following corticosteroid administration in rats fed with galactose].

Authors:  G Cremer-Bartels; O Hockwin; K Ganter; H Werry
Journal:  Ber Zusammenkunft Dtsch Ophthalmol Ges       Date:  1969

4.  Cataractogenic effect of corticosteroids on animals.

Authors:  J W Bettman; W E Fung; R G Webster; P P Noyes; N J Vincent
Journal:  Am J Ophthalmol       Date:  1968-04       Impact factor: 5.258

5.  Topical corticosteroids and galactose cataracts.

Authors:  E Cotlier; B Becker
Journal:  Invest Ophthalmol       Date:  1965-10

6.  [Corticosteroid cataracts following kidney transplantation. Investigations on the influence of additional factors upon the development of opacities (author's transl)].

Authors:  H R Koch; P Weikenmeier; M Siedek
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1975
  6 in total
  1 in total

1.  [The influence of cortisol treatment on the development of diabetic cataracts in rats (author's transl)].

Authors:  H R Koch; M Hillenblink; N Liappis
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1976
  1 in total

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