Literature DB >> 10825960

Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase.

A E Leyes1, J A Baker, C D Poulter.   

Abstract

[formula: see text] Farnesyl diphosphate (FPP) synthase from Escherichia coli catalyzes the condensation of isopentenyl diphosphate (IPP) and geranyl diphosphate (GPP) with selective removal of the pro-R hydrogen at C2 of IPP, the same stereochemistry observed for the pig liver, yeast, and avian enzymes.

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Year:  1999        PMID： 10825960     DOI： 10.1021/ol990876e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus.

Authors:  F M Hahn; L M Eubanks; C A Testa; B S Blagg; J A Baker; C D Poulter
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

2.  Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate.

Authors:  Jean-François Hoeffler; Andréa Hemmerlin; Catherine Grosdemange-Billiard; Thomas J Bach; Michel Rohmer
Journal:  Biochem J       Date:  2002-09-01       Impact factor: 3.857

3.  Deuterium-labelled isotopomers of 2-C-methyl-D-erythritol as tools for the elucidation of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis.

Authors:  L Charon; J F Hoeffler; C Pale-Grosdemange; L M Lois; N Campos; A Boronat; M Rohmer
Journal:  Biochem J       Date:  2000-03-15       Impact factor: 3.857

4.  A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.

Authors:  Tanja Sgraja; Lauris E Kemp; Nicola Ramsden; William N Hunter
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-06-30
  4 in total

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