Literature DB >> 10825958

Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct.

R A Mehl1, T P Begley.   

Abstract

[formula: see text] UV irradiation of spores results in the formation of the spore photoproduct. This novel DNA photolesion is repaired in the germinating spore in a reaction catalyzed by the spore photoproduct lyase. Model studies, using a simple bispyrimidine, suggest that this repair reaction proceeds by hydrogen abstraction from C6 of the spore photoproduct followed by beta-scission of the bond linking the two pyrimidines and back hydrogen atom transfer.

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Year:  1999        PMID： 10825958     DOI： 10.1021/ol9908676

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  21 in total

1.  DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitution.

Authors:  Alexia Chandor-Proust; Olivier Berteau; Thierry Douki; Didier Gasparutto; Sandrine Ollagnier-de-Choudens; Marc Fontecave; Mohamed Atta
Journal:  J Biol Chem       Date:  2008-10-27       Impact factor: 5.157

2.  Inter-strand photoproducts are produced in high yield within A-DNA exposed to UVC radiation.

Authors:  Thierry Douki; Grégory Laporte; Jean Cadet
Journal:  Nucleic Acids Res       Date:  2003-06-15       Impact factor: 16.971

3.  Probing the reaction mechanism of spore photoproduct lyase (SPL) via diastereoselectively labeled dinucleotide SP TpT substrates.

Authors:  Linlin Yang; Gengjie Lin; Degang Liu; Karl J Dria; Joshua Telser; Lei Li
Journal:  J Am Chem Soc       Date:  2011-06-14       Impact factor: 15.419

4.  Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange.

Authors:  Shourjo Ghose; Jonathan K Hilmer; Brian Bothner; Joan B Broderick
Journal:  FEBS Lett       Date:  2014-06-17       Impact factor: 4.124

Review 5.  Radical S-adenosylmethionine enzymes.

Authors:  Joan B Broderick; Benjamin R Duffus; Kaitlin S Duschene; Eric M Shepard
Journal:  Chem Rev       Date:  2014-01-29       Impact factor: 60.622

6.  The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase.

Authors:  R Rebeil; W L Nicholson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

7.  Spore photoproduct (SP) lyase from Bacillus subtilis specifically binds to and cleaves SP (5-thyminyl-5,6-dihydrothymine) but not cyclobutane pyrimidine dimers in UV-irradiated DNA.

Authors:  T A Slieman; R Rebeil; W L Nicholson
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

8.  Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct.

Authors:  Tilak Chandra; Sunshine C Silver; Egidijus Zilinskas; Eric M Shepard; William E Broderick; Joan B Broderick
Journal:  J Am Chem Soc       Date:  2009-02-25       Impact factor: 15.419

9.  Synthesis and EPR studies of 2'-deoxyuridines with alkynyl, rodlike linkages.

Authors:  Adam Sniady; Michael D Sevilla; Srinivasarao Meneni; Tadeusz Lis; Slawomir Szafert; Deepthi Khanduri; John M Finke; Roman Dembinski
Journal:  Chemistry       Date:  2009-08-03       Impact factor: 5.236

10.  A radical transfer pathway in spore photoproduct lyase.

Authors:  Linlin Yang; Renae S Nelson; Alhosna Benjdia; Gengjie Lin; Joshua Telser; Stefan Stoll; Ilme Schlichting; Lei Li
Journal:  Biochemistry       Date:  2013-04-22       Impact factor: 3.162
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