Literature DB >> 10823695

New cytotoxic butanolides from Lindera obtusiloba BLUME.

H C Kwon1, N I Baek, S U Choi, K R Lee.   

Abstract

Three new butanolides, 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide (1), (2Z,3S,4S)-2-(11-dodecenylidene)-3-hydroxy-4-methylbutano lide (2) and (2E,3R,4R)-2-(11-dodecenylidene)-3-hydroxy-4-methoxy-4-methylbu tanolide (3), were isolated from the stems of Lindera obtusiloba BLUME. Their chemical structures were assigned by spectroscopic evidence. They exhibited cytotoxicity against cultured human tumor cell lines with their ED50 values ranging from 3.19 to 14.63 microg/ml.

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Year:  2000        PMID： 10823695     DOI： 10.1248/cpb.48.614

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

1.  An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats.

Authors:  Jung-Ok Lee; Min-Ho Oak; Sang Hoon Jung; Dong Hyun Park; Cyril Auger; Kyoung Rak Kim; Seung-Woo Lee; Valérie B Schini-Kerth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-05-02       Impact factor: 3.000

2.  A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.

Authors:  Christian Freise; Martin Ruehl; Ulrike Erben; Ulf Neumann; Daniel Seehofer; Ki Young Kim; Wolfram Trowitzsch-Kienast; Thorsten Stroh; Martin Zeitz; Rajan Somasundaram
Journal:  BMC Complement Altern Med       Date:  2011-05-12       Impact factor: 3.659

3.  A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-κB.

Authors:  Christian Freise; Ki Young Kim; Uwe Querfeld
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-30       Impact factor: 2.629

4.  Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve.

Authors:  Chi-Lung Yang; Ho-Cheng Wu; Tsong-Long Hwang; Chu-Hung Lin; Yin-Hua Cheng; Chia-Chi Wang; Hung-Lin Kan; Yueh-Hsiung Kuo; Ih-Sheng Chen; Hsun-Shuo Chang; Ying-Chi Lin
Journal:  Molecules       Date:  2020-07-25       Impact factor: 4.411

5.  Antidepressant-Like Effects of Lindera obtusiloba Extracts on the Immobility Behavior of Rats in the Forced Swim Test.

Authors:  Dong Wook Lim; Mi-Sook Lee; Song Her; Suengmok Cho; Chang-Ho Lee; In-Ho Kim; Daeseok Han
Journal:  Molecules       Date:  2016-02-27       Impact factor: 4.411

6.  Concise Synthesis of Linderaspirone A and Bi-linderone.

Authors:  Fenfen Xiao; Wu Liu; Yunxia Wang; Qing Zhang; Xiang Li; Xiangdong Hu
Journal:  Asian J Org Chem       Date:  2013-01-11       Impact factor: 3.319

Review 7.  Therapeutic Potential of Lindera obtusiloba: Focus on Antioxidative and Pharmacological Properties.

Authors:  Md Ezazul Haque; Shofiul Azam; Rengasamy Balakrishnan; Mahbuba Akther; In-Su Kim
Journal:  Plants (Basel)       Date:  2020-12-13
  7 in total

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