P F Liddle1. 1. Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Abstract
OBJECTIVE: To examine cognitive impairment in schizophrenia and its impact on social functioning. METHOD: Cohort studies recording cognitive and social development, studies of predictors of poor community outcome, and evidence from brain imaging studies are reviewed. RESULTS: Executive function deficits, and poor performance in verbal memory, vigilance, and working memory tests are strong predictors of poor community outcome and impairment in skills learning. PET scans of regional cerebral blood flow suggest a dynamic imbalance between different cerebral areas rather than overall loss of brain function. CONCLUSION: Chronic cognitive impairment is the strongest predictor of social disability. Results suggest that the impairment of brain function associated with executive deficits is not necessarily irreversible and may therefore be treatable with appropriate drug therapy.
OBJECTIVE: To examine cognitive impairment in schizophrenia and its impact on social functioning. METHOD: Cohort studies recording cognitive and social development, studies of predictors of poor community outcome, and evidence from brain imaging studies are reviewed. RESULTS: Executive function deficits, and poor performance in verbal memory, vigilance, and working memory tests are strong predictors of poor community outcome and impairment in skills learning. PET scans of regional cerebral blood flow suggest a dynamic imbalance between different cerebral areas rather than overall loss of brain function. CONCLUSION: Chronic cognitive impairment is the strongest predictor of social disability. Results suggest that the impairment of brain function associated with executive deficits is not necessarily irreversible and may therefore be treatable with appropriate drug therapy.
Authors: Maria Jalbrzikowski; Vishnu P Murty; Patricia L Stan; Jusmita Saifullan; Daniel Simmonds; William Foran; Beatriz Luna Journal: Schizophr Res Date: 2017-11-11 Impact factor: 4.939
Authors: Michael P Hong; Janna L Guilfoyle; Lindsey N Mooney; Logan K Wink; Ernest V Pedapati; Rebecca C Shaffer; John A Sweeney; Craig A Erickson Journal: Res Dev Disabil Date: 2017-07-24
Authors: Suzanne N Avery; Maureen McHugo; Kristan Armstrong; Jennifer U Blackford; Simon Vandekar; Neil D Woodward; Stephan Heckers Journal: Schizophr Res Date: 2020-07-28 Impact factor: 4.939
Authors: Jeffrey R Bishop; James L Reilly; Margret S H Harris; Shitalben R Patel; Rick Kittles; Judith A Badner; Konasale M Prasad; Vishwajit L Nimgaonkar; Matcheri S Keshavan; John A Sweeney Journal: Psychopharmacology (Berl) Date: 2014-08-07 Impact factor: 4.530
Authors: Patricia S Goldman-Rakic; Stacy A Castner; Torgny H Svensson; Larry J Siever; Graham V Williams Journal: Psychopharmacology (Berl) Date: 2004-04-30 Impact factor: 4.530