OBJECTIVE: To examine the relationship between number of episodes and inter-episode functioning in bipolar disorder. METHOD: Sixty-four euthymic subjects with bipolar affective disorder completed the Medical Outcomes Questionnaire Short Form and the Global Assessment of Functioning Scale. Goodness-of-fit models were used to define the relation between episode number and level of function. RESULTS: Non-linear logarithmic and power relations best described the association between number of episodes and outcome. Number of past depressions was a stronger determinant of outcome than past manias. CONCLUSION: Strategies to minimize the number of episodes experienced by patients with bipolar illness must be pursued aggressively if function is to be maintained, with particular attention given to minimizing episodes of depression.
OBJECTIVE: To examine the relationship between number of episodes and inter-episode functioning in bipolar disorder. METHOD: Sixty-four euthymic subjects with bipolar affective disorder completed the Medical Outcomes Questionnaire Short Form and the Global Assessment of Functioning Scale. Goodness-of-fit models were used to define the relation between episode number and level of function. RESULTS: Non-linear logarithmic and power relations best described the association between number of episodes and outcome. Number of past depressions was a stronger determinant of outcome than past manias. CONCLUSION: Strategies to minimize the number of episodes experienced by patients with bipolar illness must be pursued aggressively if function is to be maintained, with particular attention given to minimizing episodes of depression.
Authors: Lakshmi N Yatham; Sidney H Kennedy; Sagar V Parikh; Ayal Schaffer; David J Bond; Benicio N Frey; Verinder Sharma; Benjamin I Goldstein; Soham Rej; Serge Beaulieu; Martin Alda; Glenda MacQueen; Roumen V Milev; Arun Ravindran; Claire O'Donovan; Diane McIntosh; Raymond W Lam; Gustavo Vazquez; Flavio Kapczinski; Roger S McIntyre; Jan Kozicky; Shigenobu Kanba; Beny Lafer; Trisha Suppes; Joseph R Calabrese; Eduard Vieta; Gin Malhi; Robert M Post; Michael Berk Journal: Bipolar Disord Date: 2018-03-14 Impact factor: 6.744
Authors: Alan C Swann; Barbara Geller; Robert M Post; Lori Altshuler; Kiki D Chang; Melissa P Delbello; Christopher Reist; Iver A Juster Journal: Prim Care Companion J Clin Psychiatry Date: 2005
Authors: Maria Syl D de la Cruz; Zongshan Lai; David E Goodrich; Amy M Kilbourne Journal: Arch Womens Ment Health Date: 2013-04-16 Impact factor: 3.633
Authors: Lauren B Marangell; Ellen B Dennehy; Sachiko Miyahara; Stephen R Wisniewski; Mark S Bauer; Mark Hyman Rapaport; Michael H Allen Journal: J Affect Disord Date: 2008-08-15 Impact factor: 4.839
Authors: Glenda M MacQueen; Stephanie Campbell; Bruce S McEwen; Kathryn Macdonald; Shigeko Amano; Russell T Joffe; Claude Nahmias; L Trevor Young Journal: Proc Natl Acad Sci U S A Date: 2003-01-24 Impact factor: 11.205
Authors: C M Bonnín; C Torrent; J M Goikolea; M Reinares; B Solé; M Valentí; J Sánchez-Moreno; D Hidalgo; R Tabarés-Seisdedos; A Martínez-Arán; E Vieta Journal: Eur Arch Psychiatry Clin Neurosci Date: 2013-08-03 Impact factor: 5.270