Literature DB >> 10822565

Efficient enantioselective synthesis of sertraline, a potent antidepressant, via a novel intramolecular nucleophilic addition to imine.

C Y Chen1, R A Reamer.   

Abstract

[formula: see text] An efficient enantioselective synthesis of sertraline, an antidepressant, utilizing anionic imine ring closure is described.

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Year:  1999        PMID： 10822565     DOI： 10.1021/ol990608g

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy.

Authors:  Cassandra L Schrank; Michael W Danneman; Emily A Prebihalo; Robert E Anderson; Tyler J Gibson; William M Wuest; Richard J Mullins
Journal:  Tetrahedron Lett       Date:  2020-04-18       Impact factor: 2.415

2.  Asymmetric synthesis of nonracemic primary amines via spiroborate-catalyzed reduction of pure (E)- and (Z)-O-benzyloximes: applications toward the synthesis of calcimimetic agents.

Authors:  Wenhua Ou; Sandraliz Espinosa; Héctor J Meléndez; Silvia M Farré; Jaime L Alvarez; Valerie Torres; Ileanne Martínez; Kiara M Santiago; Margarita Ortiz-Marciales
Journal:  J Org Chem       Date:  2013-05-13       Impact factor: 4.354
  2 in total

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