| Literature DB >> 1082146 |
H L Klawans, D J D'Amico, B C Patel.
Abstract
The administration of 5-hydroxytryptophan to intact guinea pigs results in rhythmic myoclonic behavior. This behavior is blocked acutely by methysergide, but is intensified in animals chronically pretreated with methysergide. Brain serotonin concentrations of guinea pigs pretreated with methysergide did not differ from saline-treated animals. These results are compatible with the hypothesis that prolonged methysergide administration can result in pharmacologically-induced denervation hypersensitivity at central serotonin receptors.Entities:
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Year: 1975 PMID： 1082146 DOI： 10.1007/bf00428910
Source DB: PubMed Journal: Psychopharmacologia