Literature DB >> 1082139

Factor-VIII-related antigen: multiple molecular forms in human plasma.

T S Zimmerman, J Roberts, T S Edgington.   

Abstract

Analysis of Factor-VIII-related antigen (vWAg) in normal plasma by crossed immunoelectrophoresis reveals an asymmetric pattern indicative of molecular heterogeneity. This asymmetric pattern apparently results from the presence of multiple molecular forms of VWAg with distinct, though partially overlapping, mobilities on crossed immunoelectrophoresis. Evidence for this conclusion has been obtained by separating these forms, one from another, utilizing cryoprecipitation, agarose gel chromatography, and ion-exchange chromatography. Variation in the relative destribution of VWAg forms in liver disease and disseminated intravascular coagulation suggests that the processes which govern generation and/or breakdown of these forms can be altered by disease.

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Year:  1975        PMID： 1082139      PMCID： PMC388888          DOI： 10.1073/pnas.72.12.5121

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

1.  Determination of the von Willebrand's disease antigen (factor VIII-related antigen) in plasma by quantitative immunoelectrophoresis.

Authors:  T S Zimmerman; L W Hoyer; L Dickson; T S Edgington
Journal:  J Lab Clin Med       Date:  1975-07

2.  Inherited variants of factor-VIII-related protein in von Willebrand's disease.

Authors:  I R Peake; A L Bloom; J C Giddings
Journal:  N Engl J Med       Date:  1974-07-18       Impact factor: 91.245

3.  Von Willebrand factor: dissociation from antihemophilic factor procoagulant activity.

Authors:  H J Weiss; I W Hoyer
Journal:  Science       Date:  1973-12-14       Impact factor: 47.728

4.  Isolation and characterization of human Factor VIII (antihemophilic factor).

Authors:  M E Legaz; G Schmer; R B Counts; E W Davie
Journal:  J Biol Chem       Date:  1973-06-10       Impact factor: 5.157

5.  Elevated antihemophilic factor (AHF, factor VIII) procoagulant activity and AHF-like antigen in alcoholic cirrhosis of the liver.

Authors:  A J Green; O D Ratnoff
Journal:  J Lab Clin Med       Date:  1974-02

6.  A variant of factor 8 related antigen.

Authors:  P B Kernoff; R Gruson; C R Rizza
Journal:  Br J Haematol       Date:  1974-03       Impact factor: 6.998

7.  Studies of the human factor VIII/von Willebrand's factor protein I. Comparison of the protein found in normal, von Willebrand's disease and hemophilia A.

Authors:  H R Gralnick; B S Coller; S L Marchesi
Journal:  Thromb Res       Date:  1975-02       Impact factor: 3.944

8.  Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.

Authors:  T S Zimmerman; O D Ratnoff; A E Powell
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808

9.  Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content.

Authors:  H J Weiss; L W Hoyer; F R Rickles; A Varma; J Rogers
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

10.  Factor VIII coagulant activity and factor VIII-like antigen: independent molecular entities.

Authors:  T S Zimmerman; T S Edgington
Journal:  J Exp Med       Date:  1973-10-01       Impact factor: 14.307
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  15 in total

1.  A photographically monitored enhanced luminescence enzyme immunoassay for factor VIII related antigen.

Authors:  H X Wang; G H Thorpe; L J Kricka; J George
Journal:  J Tongji Med Univ       Date:  1986

2.  von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

Authors:  R R Montgomery; T S Zimmerman
Journal:  J Clin Invest       Date:  1978-06       Impact factor: 14.808

3.  Factor VIII, von Willebrand's disease, and atherosclerosis.

Authors: 
Journal:  Br Med J       Date:  1977-11-12

4.  Structural analysis of factor VIII antigen in von Willebrand disease.

Authors:  R L Nachman; E A Jaffe; C Miller; W T Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

5.  Macromolecular factor VIII complex: functional and structural heterogeneity observed in von Willebrand swine with transfusion.

Authors:  T R Griggs; J S Potter; S B McClanahan; W P Webster; K M Brinkhous
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

6.  The von Willebrand-syndrome.

Authors:  I Scharrer
Journal:  Blut       Date:  1983-09

7.  Von Willebrand's disease: a clinical and molecular enigma. Twelfth Annual Paul M. Aggeler Memorial Lecture.

Authors:  R L Nachman
Journal:  West J Med       Date:  1982-04

8.  Abnormal erythrocyte membrane protein pattern in severe megaloblastic anemia.

Authors:  S K Ballas
Journal:  J Clin Invest       Date:  1978-04       Impact factor: 14.808

9.  Human platelet membrane receptor for bovine von Willebrand factor (platelet aggregating factor): an integral membrane glycoprotein.

Authors:  H A Cooper; K J Clemetson; E F Lüscher
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

10.  Active release of human platelet factor VIII-related antigen by adenosine diphosphate, collagen, and thrombin.

Authors:  J Koutts; P N Walsh; E F Plow; J W Fenton; B N Bouma; T S Zimmerman
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808
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