| Literature DB >> 10821369 |
M J Arranz, J Munro, J Birkett, A Bolonna, D Mancama, M Sodhi, K P Lesch, J F Meyer, P Sham, D A Collier, R M Murray, R W Kerwin.
Abstract
We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/- 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.Entities:
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Year: 2000 PMID： 10821369 DOI： 10.1016/s0140-6736(00)02221-2
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321