Literature DB >> 10821064

Diterpenoids from Euphorbia peplus.

J Hohmann, F Evanics, L Berta, T Bartók.   

Abstract

From a pro-inflammatory active extract of Euphorbia peplus, two new diterpene polyesters based on the pepluane and jatrophane skeletons were isolated, together with four known ingenane and jatrophane diterpenes. The structures were determined on the basis of extensive NMR studies. Ingenol 3-angelate, which was obtained for the first time from this plant, is an irritant toxin with high activity.

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Year:  2000        PMID： 10821064     DOI： 10.1055/s-2000-8568

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

1.  Gene discovery and virus-induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids in Euphorbia peplus.

Authors:  Tomasz Czechowski; Edith Forestier; Sandesh H Swamidatta; Alison D Gilday; Amy Cording; Tony R Larson; David Harvey; Yi Li; Zhesi He; Andrew J King; Geoffrey D Brown; Ian A Graham
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-18       Impact factor: 12.779

2.  Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters.

Authors:  Andrew J King; Geoffrey D Brown; Alison D Gilday; Tony R Larson; Ian A Graham
Journal:  Plant Cell       Date:  2014-08-29       Impact factor: 11.277

3.  Bioactive diterpenoid metabolism and cytotoxic activities of genetically transformed Euphorbia lathyris roots.

Authors:  Vincent A Ricigliano; Vincent P Sica; Sonja L Knowles; Nicole Diette; Dianella G Howarth; Nicholas H Oberlies
Journal:  Phytochemistry       Date:  2020-09-25       Impact factor: 4.072

4.  Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Authors:  Dan Luo; Roberta Callari; Britta Hamberger; Sileshi Gizachew Wubshet; Morten T Nielsen; Johan Andersen-Ranberg; Björn M Hallström; Federico Cozzi; Harald Heider; Birger Lindberg Møller; Dan Staerk; Björn Hamberger
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-09       Impact factor: 11.205

5.  Biosynthesis of angelyl-CoA in Saccharomyces cerevisiae.

Authors:  Roberta Callari; David Fischer; Harald Heider; Nora Weber
Journal:  Microb Cell Fact       Date:  2018-05-12       Impact factor: 5.328

Review 6.  Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Authors:  Atanas G Atanasov; Birgit Waltenberger; Eva-Maria Pferschy-Wenzig; Thomas Linder; Christoph Wawrosch; Pavel Uhrin; Veronika Temml; Limei Wang; Stefan Schwaiger; Elke H Heiss; Judith M Rollinger; Daniela Schuster; Johannes M Breuss; Valery Bochkov; Marko D Mihovilovic; Brigitte Kopp; Rudolf Bauer; Verena M Dirsch; Hermann Stuppner
Journal:  Biotechnol Adv       Date:  2015-08-15       Impact factor: 14.227

7.  Ingol and Ingenol-Type Diterpenes from Euphorbia trigona Miller with Keratinocyte Inhibitory Activity.

Authors:  Reham Hammadi; Norbert Kúsz; Csilla Zsuzsanna Dávid; Zoltán Behány; László Papp; Lajos Kemény; Judit Hohmann; Lóránt Lakatos; Andrea Vasas
Journal:  Plants (Basel)       Date:  2021-06-14

Review 8.  Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984-2019).

Authors:  Maryam Fattahian; Mustafa Ghanadian; Zulfiqar Ali; Ikhlas A Khan
Journal:  Phytochem Rev       Date:  2020-04-13       Impact factor: 7.741

9.  Ingenol Disoxate: A Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties for Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers.

Authors:  Malene Bertelsen; Martin Stahlhut; Gunnar Grue-Sørensen; Xifu Liang; Gitte Bach Christensen; Kresten Skak; Karen Margrethe Engell; Thomas Högberg
Journal:  Dermatol Ther (Heidelb)       Date:  2016-08-08
  9 in total

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