Literature DB >> 10819531

The genetics of inherited breast cancer.

S A Gayther1, P D Pharoah, B A Ponder.   

Abstract

The isolation of BRCA1 and BRCA2 has greatly increased our understanding of the genetics of inherited breast and ovarian cancer although the functions of these genes are not yet fully understood. We will discuss the current state of knowledge about the function of BRCA1 and BRCA2 and summarize the cancer risks in women carrying a BRCA1 or BRCA2 mutation. We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.

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Year:  1998        PMID： 10819531     DOI： 10.1023/a:1018779830743

Source DB:  PubMed          Journal:  J Mammary Gland Biol Neoplasia        ISSN： 1083-3021            Impact factor:   2.673


  84 in total

1.  A low proportion of BRCA2 mutations in Finnish breast cancer families.

Authors:  P Vehmanen; L S Friedman; H Eerola; L Sarantaus; S Pyrhönen; B A Ponder; T Muhonen; H Nevanlinna
Journal:  Am J Hum Genet       Date:  1997-05       Impact factor: 11.025

2.  Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer.

Authors:  M Krainer; S Silva-Arrieta; M G FitzGerald; A Shimada; C Ishioka; R Kanamaru; D J MacDonald; H Unsal; D M Finkelstein; A Bowcock; K J Isselbacher; D A Haber
Journal:  N Engl J Med       Date:  1997-05-15       Impact factor: 91.245

3.  A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families.

Authors:  T Peelen; M van Vliet; A Petrij-Bosch; R Mieremet; C Szabo; A M van den Ouweland; F Hogervorst; R Brohet; M J Ligtenberg; E Teugels; R van der Luijt; A H van der Hout; J J Gille; G Pals; I Jedema; R Olmer; I van Leeuwen; B Newman; M Plandsoen; M van der Est; G Brink; S Hageman; P J Arts; M M Bakker; P Devilee
Journal:  Am J Hum Genet       Date:  1997-05       Impact factor: 11.025

4.  Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

Authors:  D Ford; D F Easton; M Stratton; S Narod; D Goldgar; P Devilee; D T Bishop; B Weber; G Lenoir; J Chang-Claude; H Sobol; M D Teare; J Struewing; A Arason; S Scherneck; J Peto; T R Rebbeck; P Tonin; S Neuhausen; R Barkardottir; J Eyfjord; H Lynch; B A Ponder; S A Gayther; M Zelada-Hedman
Journal:  Am J Hum Genet       Date:  1998-03       Impact factor: 11.025

5.  Frequency of breast cancer attributable to BRCA1 in a population-based series of American women.

Authors:  B Newman; H Mu; L M Butler; R C Millikan; P G Moorman; M C King
Journal:  JAMA       Date:  1998-03-25       Impact factor: 56.272

6.  BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history.

Authors:  K E Malone; J R Daling; J D Thompson; C A O'Brien; L V Francisco; E A Ostrander
Journal:  JAMA       Date:  1998-03-25       Impact factor: 56.272

7.  Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene.

Authors:  S A Gayther; J Mangion; P Russell; S Seal; R Barfoot; B A Ponder; M R Stratton; D Easton
Journal:  Nat Genet       Date:  1997-01       Impact factor: 38.330

8.  Germ-line BRCA1 mutations in women with sporadic breast cancer: clinical correlations.

Authors:  E Garcia-Patiño; B Gomendio; M Provencio; J M Silva; J M Garcia; P España; F Bonilla
Journal:  J Clin Oncol       Date:  1998-01       Impact factor: 44.544

9.  The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals.

Authors:  J P Struewing; D Abeliovich; T Peretz; N Avishai; M M Kaback; F S Collins; L C Brody
Journal:  Nat Genet       Date:  1995-10       Impact factor: 38.330

10.  Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

Authors:  S D Merajver; T M Pham; R F Caduff; M Chen; E L Poy; K A Cooney; B L Weber; F S Collins; C Johnston; T S Frank
Journal:  Nat Genet       Date:  1995-04       Impact factor: 38.330
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  5 in total

1.  Direct DNA binding by Brca1.

Authors:  T T Paull; D Cortez; B Bowers; S J Elledge; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  BRCA2 suppresses cell proliferation via stabilizing MAGE-D1.

Authors:  Xin-xia Tian; Deepak Rai; Jun Li; Chaozhong Zou; Yujie Bai; David Wazer; Vimla Band; Qingshen Gao
Journal:  Cancer Res       Date:  2005-06-01       Impact factor: 12.701

3.  Long-term outcomes of breast cancer in women aged 30 years or younger, based on family history, pathology and BRCA1/BRCA2/TP53 status.

Authors:  D G R Evans; A Moran; R Hartley; J Dawson; B Bulman; F Knox; A Howell; F Lalloo
Journal:  Br J Cancer       Date:  2010-03-16       Impact factor: 7.640

4.  Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group.

Authors: 
Journal:  Br J Cancer       Date:  2000-11       Impact factor: 7.640

5.  EMSY links breast cancer gene 2 to the 'Royal Family'.

Authors:  Jun Yao; Kornelia Polyak
Journal:  Breast Cancer Res       Date:  2004-07-19       Impact factor: 6.466
  5 in total

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