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Literature DB >> 10819516

Transferrin and prolactin transcytosis in the lactating mammary epithelial cell.

Abstract

The mammary epithelial cell ferries constituents originating from blood and from stromal cells, into milk, by transcytosis. Morphological analysis of a membrane marker of transcytosis in the lactating mammary epithelial cell showed that very rapid endocytosis of surface membrane occurs from both the basolateral and the apical side of the cell. In both cases, membrane trafficking between endosomes and the Golgi complex allows communication between the endocytic and the biosynthetic pathways. Transferrin and prolactin are internalized in mammary cells and transported through multivesicular bodies and Golgi stacks. They are released into milk via different types of secretory vesicles, prolactin being carried in secretory vesicles containing casein micelles. Consequences of the intracellular transport of these proteins and physiological benefits for cell function are discussed.

Entities: Gene

Mesh：

Substances：
Transferrin
Prolactin

Year: 1998 PMID： 10819516 DOI： 10.1023/a:1018767528017

Source DB: PubMed Journal: J Mammary Gland Biol Neoplasia ISSN： 1083-3021 Impact factor: 2.673

50 in total

1. Targeting of membrane proteins to endosomes and lysosomes.

Authors: I V Sandoval; O Bakke
Journal: Trends Cell Biol Date: 1994-08 Impact factor: 20.808

Review 2. The role of clathrin, adaptors and dynamin in endocytosis.

Authors: M S Robinson
Journal: Curr Opin Cell Biol Date: 1994-08 Impact factor: 8.382

3. Brefeldin A differently affects basal and prolactin-stimulated milk protein secretion in lactating rabbit mammary epithelial cells.

Authors: A Pauloin; S Delpal; E Chanat; F Lavialle; A Aubourg; M Ollivier-Bousquet
Journal: Eur J Cell Biol Date: 1997-04 Impact factor: 4.492

Review 4. Prolactin signaling in mammary gland development.

Authors: L Hennighausen; G W Robinson; K U Wagner; W Liu
Journal: J Biol Chem Date: 1997-03-21 Impact factor: 5.157

Review 5. The emergence of clathrin-independent pinocytic pathways.

Authors: C Lamaze; S L Schmid
Journal: Curr Opin Cell Biol Date: 1995-08 Impact factor: 8.382

Review 6. Hormones and growth factors in milk.

Authors: C E Grosvenor; M F Picciano; C R Baumrucker
Journal: Endocr Rev Date: 1993-12 Impact factor: 19.871

7. Plasma protein metabolism during lactation in the rabbit.

Authors: S M Jordan; E H Morgan
Journal: Am J Physiol Date: 1970-12

Review 8. Cleavage of prolactin by its target organs and the possible significance of this process.

Authors: C S Nicoll
Journal: J Mammary Gland Biol Neoplasia Date: 1997-01 Impact factor: 2.673

9. Crotoxin, a phospholipase A2 neurotoxin from snake venom, interacts with epithelial mammary cells, is internalized and induces secretion.

Authors: M Ollivier-Bousquet; F Radvanyi; C Bon
Journal: Mol Cell Endocrinol Date: 1991-11 Impact factor: 4.102

10. Deficiency of (n-6) but not (n-3) polyunsaturated fatty acids inhibits the secretagogue effect of prolactin in lactating rat mammary epithelial cells.

Authors: M Ollivier-Bousquet; P Guesnet; T Seddiki; G Durand
Journal: J Nutr Date: 1993-12 Impact factor: 4.798

10 in total

Review 1. Paradigm-shifters: phosphorylated prolactin and short prolactin receptors.

Authors: KuangTzu Huang; Eric Ueda; YenHao Chen; Ameae M Walker
Journal: J Mammary Gland Biol Neoplasia Date: 2008-01-25 Impact factor: 2.673

Review 2. Proteolytic Systems in Milk: Perspectives on the Evolutionary Function within the Mammary Gland and the Infant.

Authors: David C Dallas; Niamh M Murray; Junai Gan
Journal: J Mammary Gland Biol Neoplasia Date: 2015-07-16 Impact factor: 2.673

Transferrin and prolactin transcytosis in the lactating mammary epithelial cell.

1. Targeting of membrane proteins to endosomes and lysosomes.

Review 2. The role of clathrin, adaptors and dynamin in endocytosis.

3. Brefeldin A differently affects basal and prolactin-stimulated milk protein secretion in lactating rabbit mammary epithelial cells.

Review 4. Prolactin signaling in mammary gland development.

Review 5. The emergence of clathrin-independent pinocytic pathways.

Review 6. Hormones and growth factors in milk.

7. Plasma protein metabolism during lactation in the rabbit.

Review 8. Cleavage of prolactin by its target organs and the possible significance of this process.

9. Crotoxin, a phospholipase A2 neurotoxin from snake venom, interacts with epithelial mammary cells, is internalized and induces secretion.

10. Deficiency of (n-6) but not (n-3) polyunsaturated fatty acids inhibits the secretagogue effect of prolactin in lactating rat mammary epithelial cells.

Review 1. Paradigm-shifters: phosphorylated prolactin and short prolactin receptors.

Review 2. Proteolytic Systems in Milk: Perspectives on the Evolutionary Function within the Mammary Gland and the Infant.

3. Prolactin promotes the secretion of active cathepsin D at the basal side of rat mammary acini.

Review 4. Milk secretion: The role of SNARE proteins.

Review 5. Colostrogenesis: IgG1 transcytosis mechanisms.

Review 6. What can we learn from rodents about prolactin in humans?

7. Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta.

Review 8. The Immunology of Mammary Gland of Dairy Ruminants between Healthy and Inflammatory Conditions.

Review 9. The Functional Power of the Human Milk Proteome.

10. Gene regulatory networks in lactation: identification of global principles using bioinformatics.