Secretion of milk proteins.

Mammary epithelial cells secrete milk proteins in a polarized manner from their apical surface during lactation. These secreted proteins are either synthesized by the mammary cells or are transported by transcytosis from blood plasma. The intracellular trafficking pathways by which milk proteins are secreted are known in general outline. In this review the basic cell biology of the mammary epithelial cell secretory pathway is considered in relation to what is known in more detail for other cell types. In addition, potential points of control of protein secretion are examined. The secretory biology of mammary epithelial cells has not been characterized extensively in recent years and, while some aspects are well understood, other key issues, which still remain to be resolved, have been highlighted.