S Rosenstock1, T Jørgensen, L Andersen, O Bonnevie. 1. Copenhagen County Centre of Preventive Medicine, Glostrup University Hospital, Glostrup, Denmark. rosenstock.s@dadlnet.dk
Abstract
STUDY OBJECTIVES: To assess the incidence of seroconversion and seroreversion in IgG antibodies to Helicobacter pylori within a 11 year observation period using these events as markers for acquisition and loss of the infection, respectively. DESIGN: Population based prospective cohort study. SETTING: Northern part of Copenhagen County, Denmark. PARTICIPANTS AND METHODS: A random sample of 2527 Danish adults were examined and blood obtained in 1983 and in 1994. Matching pairs of sera were analysed for the presence of IgG and IgM antibodies to H pylori with an in house enzyme linked immunosorbent assay. Participants who were seronegative at study entry and seropositive at follow up and had a fourfold increase in baseline IgG antibody levels were categorised as seroconverters and regarded as having acquired H pylori infection. Participants who were seropositive at study entry and had at least a fourfold decrease in baseline IgG antibody levels at follow up were assumed to have lost the infection (seroreverters). RESULTS: The seroprevalence of H pylori infection was 24.7 (95% confidence intervals (95% CI) 23.0, 26.4) % in 1983 and 24.5 (95% CI 22.8, 26. 2) % in 1994. A total of 14 participants seroconverted within the observation period (cumulative 11 year incidence proportion: 1.0 (95% CI 0.5, 1.5) %). Having increased IgM antibody levels at study entry significantly increased the likelihood of IgG seroconversion (relative risk 6.4 (95% CI 2.1, 19.6). Seroreversion was seen in 48 participants (cumulative 11 year incidence proportion: 7.7 (95% CI 5. 6, 9.8) %). CONCLUSIONS: Changes in H pylori infection status with time are rare in Danish adults. Few adults become infected with H pylori in Denmark.
STUDY OBJECTIVES: To assess the incidence of seroconversion and seroreversion in IgG antibodies to Helicobacter pylori within a 11 year observation period using these events as markers for acquisition and loss of the infection, respectively. DESIGN: Population based prospective cohort study. SETTING: Northern part of Copenhagen County, Denmark. PARTICIPANTS AND METHODS: A random sample of 2527 Danish adults were examined and blood obtained in 1983 and in 1994. Matching pairs of sera were analysed for the presence of IgG and IgM antibodies to H pylori with an in house enzyme linked immunosorbent assay. Participants who were seronegative at study entry and seropositive at follow up and had a fourfold increase in baseline IgG antibody levels were categorised as seroconverters and regarded as having acquired H pylori infection. Participants who were seropositive at study entry and had at least a fourfold decrease in baseline IgG antibody levels at follow up were assumed to have lost the infection (seroreverters). RESULTS: The seroprevalence of H pylori infection was 24.7 (95% confidence intervals (95% CI) 23.0, 26.4) % in 1983 and 24.5 (95% CI 22.8, 26. 2) % in 1994. A total of 14 participants seroconverted within the observation period (cumulative 11 year incidence proportion: 1.0 (95% CI 0.5, 1.5) %). Having increased IgM antibody levels at study entry significantly increased the likelihood of IgG seroconversion (relative risk 6.4 (95% CI 2.1, 19.6). Seroreversion was seen in 48 participants (cumulative 11 year incidence proportion: 7.7 (95% CI 5. 6, 9.8) %). CONCLUSIONS: Changes in H pylori infection status with time are rare in Danish adults. Few adults become infected with H pylori in Denmark.
Authors: E J Kuipers; A S Peña; G van Kamp; A M Uyterlinde; G Pals; N F Pels; E Kurz-Pohlmann; S G Meuwissen Journal: Lancet Date: 1993-08-07 Impact factor: 79.321
Authors: G Gasbarrini; S Pretolani; F Bonvicini; M R Gatto; E Tonelli; F Mégraud; K Mayo; G Ghironzi; G Giulianelli; M Grassi Journal: Gut Date: 1995-06 Impact factor: 23.059
Authors: Lars Agréus; Per M Hellström; Nicholas J Talley; Bengt Wallner; Anna Forsberg; Michael Vieth; Lothar Veits; Karin Björkegren; Lars Engstrand; Anna Andreasson Journal: United European Gastroenterol J Date: 2015-12-18 Impact factor: 4.623
Authors: Ayesha Shah; Nicholas J Talley; Marjorie Walker; Natasha Koloski; Mark Morrison; Daniel Burger; Jane M Andrews; Michael McGuckin; Mike Jones; Gerald Holtmann Journal: Dig Dis Sci Date: 2017-03-09 Impact factor: 3.199
Authors: M Constanza Camargo; Yasuyuki Goto; Jovanny Zabaleta; Douglas R Morgan; Pelayo Correa; Charles S Rabkin Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-10-25 Impact factor: 4.254
Authors: Sharon Perry; Maria de la Luz Sanchez; Shufang Yang; Thomas D Haggerty; Philip Hurst; Guillermo Perez-Perez; Julie Parsonnet Journal: Emerg Infect Dis Date: 2006-11 Impact factor: 6.883