Literature DB >> 10817746

Cyclic AMP and fluconazole resistance in Saccharomyces cerevisiae.

D P Kontoyiannis1, S Rupp.   

Abstract

Cyclic AMP (cAMP) is involved in the stress response in Saccharomyces cerevisiae. We show that cAMP is required for resistance to fluconazole in S. cerevisiae. In addition, activation of Ras2, a regulator of cAMP generation, results in some protection from fluconazole toxicity in a fashion independent of the efflux transporter Pdr5p.

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Year:  2000        PMID： 10817746      PMCID： PMC89950          DOI： 10.1128/AAC.44.6.1743-1744.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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