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Literature DB >> 10817736

Comparative in vitro activities of clinafloxacin and trovafloxacin against 1,000 isolates of bacteroides fragilis group: effect of the medium on test results.

D R Snydman¹, N V Jacobus, L A McDermott, S E Supran.

Abstract

The in vitro antibacterial activities of clinafloxacin, trovafloxacin, ciprofloxacin, and cefoxitin against 1,000 clinical isolates of Bacteroides fragilis group were compared by agar dilution in brucella blood agar (BBA) and Wilkins Chalgren agar (WCA). Significantly higher geometric mean MICs for the three quinolones and cefoxitin (P<0.001) were obtained in BBA than in WCA. Regardless of medium, clinafloxacin was slightly more active than trovafloxacin. The activity of clinafloxacin and trovafloxacin was greater than that of cefoxitin against B. distasonis, B. ovatus, and B. thetaiotaomicron but lower against B. vulgatus. High cross resistance between trovafloxacin and clinafloxacin was observed.

Entities: Chemical Disease Species

Mesh：

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Year: 2000 PMID： 10817736 PMCID： PMC89940 DOI： 10.1128/AAC.44.6.1710-1712.2000

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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3. In-vitro activity of clinafloxacin, trovafloxacin, and ciprofloxacin.

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5. The in-vitro activity of trovafloxacin and nine other antimicrobials against 413 anaerobic bacteria.

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6. In vitro activities of trovafloxacin against 557 strains of anaerobic bacteria.

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7. Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms.

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8. Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes.

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2. Multicenter survey of the changing in vitro antimicrobial susceptibilities of clinical isolates of Bacteroides fragilis group, Prevotella, Fusobacterium, Porphyromonas, and Peptostreptococcus species.

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