Literature DB >> 10817588

Functional human heme oxygenase has a neuroprotective effect on adult rat ganglion cells after pressure-induced ischemia.

K A Hegazy1, M W Dunn, S C Sharma.   

Abstract

Adult retina subjected to transient ischemia and reperfusion leads to controlled retinal ganglion cell (RGC) death over a period. Modification of intracellular mechanisms through a specific adenoviral vector containing the hemoxygenase gene (HO-1) provides avenues for RGC survival following HO-1 gene transfer and ischemia. RGC death rate was reduced by an average of 15% at 1, 2 and 3 weeks. A significant number of RGC transfected with functional HO-1 survived ischemic insults. Pharmacological stimulation of HO-1 may constitute a novel therapeutic approach to rescuing RGC experiencing ischemic/reperfusion injury.

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Year:  2000        PMID： 10817588     DOI： 10.1097/00001756-200004270-00008

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  8 in total

1.  Neuroprotective effect of the novel Na+/Ca2+ channel blocker NS-7 on rat retinal ganglion cells.

Authors:  Shinichiro Saito; Masaaki Ohashi; Akira Naito; Yasuhiro Fukaya; Yasuyuki Suzuki; Makoto Araie
Journal:  Jpn J Ophthalmol       Date:  2005 Sep-Oct       Impact factor: 2.447

2.  Knockdown of heme oxygenase-2 impairs corneal epithelial cell wound healing.

Authors:  Adna Halilovic; Kiran A Patil; Lars Bellner; Giuseppina Marrazzo; Kirkland Castellano; Giuseppe Cullaro; Michael W Dunn; Michal Laniado Schwartzman
Journal:  J Cell Physiol       Date:  2011-07       Impact factor: 6.384

Review 3.  Antioxidant enzyme gene transfer for ischemic diseases.

Authors:  Jian Wu; James G Hecker; Nipavan Chiamvimonvat
Journal:  Adv Drug Deliv Rev       Date:  2009-02-20       Impact factor: 15.470

4.  Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance.

Authors:  Yanli Zhu; Lihong Zhang; Jeffrey M Gidday
Journal:  J Ocul Pharmacol Ther       Date:  2008-12       Impact factor: 2.671

5.  Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin.

Authors:  Lars Bellner; Marco Vitto; Kiran A Patil; Michael W Dunn; Raymond Regan; Michal Laniado-Schwartzman
Journal:  Exp Eye Res       Date:  2008-06-17       Impact factor: 3.467

6.  Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects.

Authors:  Ruiping Song; Masatoshi Kubo; Danielle Morse; Zhihong Zhou; Xuchen Zhang; James H Dauber; James Fabisiak; Sean M Alber; Simon C Watkins; Brian S Zuckerbraun; Leo E Otterbein; Wen Ning; Tim D Oury; Patty J Lee; Kenneth R McCurry; Augustine M K Choi
Journal:  Am J Pathol       Date:  2003-07       Impact factor: 4.307

7.  Prevention of methylmercury-induced mitochondrial depolarization, glutathione depletion and cell death by 15-deoxy-delta-12,14-prostaglandin J(2).

Authors:  Jason Y Chang; Pao-Feng Tsai
Journal:  Neurotoxicology       Date:  2008-08-19       Impact factor: 4.294

Review 8.  Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection.

Authors:  Lin Cheng; Honghua Yu; Naihong Yan; Kunbei Lai; Mengqing Xiang
Journal:  Front Cell Neurosci       Date:  2017-02-27       Impact factor: 5.505
  8 in total

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