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Literature DB >> 10817498

Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.

G Liu¹, P Ghadirian, D Vesprini, N Hamel, A J Paradis, G Lal, S Gallinger, S A Narod, W D Foulkes.

Abstract

A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer.

Entities: Disease Gene

Mesh：

Substances：

Year: 2000 PMID： 10817498 PMCID： PMC2374522 DOI： 10.1054/bjoc.2000.1221

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

13 in total

1. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility.

Authors: X Xu; K T Kelsey; J K Wiencke; J C Wain; D C Christiani
Journal: Cancer Epidemiol Biomarkers Prev Date: 1996-09 Impact factor: 4.254

Review 2. Genetic factors in individual responses to environmental exposures.

Authors: A Hirvonen
Journal: J Occup Environ Med Date: 1995-01 Impact factor: 2.162

3. Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis.

Authors: Z Y Zhang; M J Fasco; L Huang; F P Guengerich; L S Kaminsky
Journal: Cancer Res Date: 1996-09-01 Impact factor: 12.701

Review 4. Pancreatic adenocarcinoma: epidemiology and genetics.

Authors: T Y Flanders; W D Foulkes
Journal: J Med Genet Date: 1996-11 Impact factor: 6.318

5. Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study.

Authors: W D Foulkes; J S Brunet; W Sieh; M J Black; G Shenouda; S A Narod
Journal: BMJ Date: 1996-09-21

6. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.

Authors: S Pemble; K R Schroeder; S R Spencer; D J Meyer; E Hallier; H M Bolt; B Ketterer; J B Taylor
Journal: Biochem J Date: 1994-05-15 Impact factor: 3.857

7. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.

Authors: S Zhong; A H Wyllie; D Barnes; C R Wolf; N K Spurr
Journal: Carcinogenesis Date: 1993-09 Impact factor: 4.944

Review 8. Nutrition and pancreatic cancer.

Authors: G R Howe; J D Burch
Journal: Cancer Causes Control Date: 1996-01 Impact factor: 2.506

9. Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.

Authors: H Bartsch; C Malaveille; A B Lowenfels; P Maisonneuve; A Hautefeuille; P Boyle
Journal: Eur J Cancer Prev Date: 1998-06 Impact factor: 2.497

10. Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer.

Authors: H C Lee; Y B Yoon; C Y Kim
Journal: Korean J Intern Med Date: 1997-06 Impact factor: 2.884

14 in total

Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.

1. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility.

Review 2. Genetic factors in individual responses to environmental exposures.

3. Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis.

Review 4. Pancreatic adenocarcinoma: epidemiology and genetics.

5. Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study.

6. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.

7. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.

Review 8. Nutrition and pancreatic cancer.

9. Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.

10. Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer.

1. Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk.

2. Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer.

3. Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Review 4. Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.

5. Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis.

6. The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP-SNP Interaction in Chinese Women.

7. Significant association between GSTT1 null genotype and susceptibility to pancreatic cancer.

8. Associations of GSTM1 and GSTT1 polymorphisms with pancreatic cancer risk: evidence from a meta-analysis.

Review 9. Molecular epidemiology of pancreatic cancer.

10. GSTT1 null genotype contributes to lung cancer risk in asian populations: a meta-analysis of 23 studies.