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Literature DB >> 1081666

T cell leukaemia in the rat: the pathophysiology.

Abstract

A new transplantable lymphocytic leukaemia of the inbred Hooded Oxford strain of rat is described. Fewer than 10 cells will transfer to syngeneic recipients. Leukaemic cells bear the surface markers of thymus-derived (T) cells and recirculate from blood to lymph. In contrast to the usual thymic lymphomas of rodents the pathophysiology of the disease bears a close resemblance to human acute lymphoblastic leukaemia.

Entities: Disease Species

Mesh：

Year: 1975 PMID： 1081666 DOI： 10.3109/00313027509094412

Source DB: PubMed Journal: Pathology ISSN： 0031-3025 Impact factor: 5.306

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Cited

9 in total

1. IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo.

Authors: Margherita Boieri; Aina Ulvmoen; Amanda Sudworth; Clare Lendrem; Matthew Collin; Anne M Dickinson; Lise Kveberg; Marit Inngjerdingen
Journal: Oncoimmunology Date: 2017-01-17 Impact factor: 8.110

2. Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor.

Authors: W A Jefferies; M R Brandon; A F Williams; S V Hunt
Journal: Immunology Date: 1985-02 Impact factor: 7.397

3. Lymphocyte expression of a 90 kD brush border antigen.

Authors: E H Van Leer; P Moullier; P Ronco; P Verroust
Journal: Clin Exp Immunol Date: 1987-03 Impact factor: 4.330

4. The carriage and delivery of substances to lymphatic tissues by recirculating lymphocytes. II. Long-term selective irradiation of the spleen and lymph nodes by deposition of indium-114m.

Authors: M Birch; H L Sharma; E B Bell; W L Ford
Journal: Immunology Date: 1986-07 Impact factor: 7.397

T cell leukaemia in the rat: the pathophysiology.

1. IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo.

2. Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor.

3. Lymphocyte expression of a 90 kD brush border antigen.

4. The carriage and delivery of substances to lymphatic tissues by recirculating lymphocytes. II. Long-term selective irradiation of the spleen and lymph nodes by deposition of indium-114m.

5. Rat lymphocyte differentiation antigens detected by rabbit antiserum to thymocytes and leukaemic cells.

6. Effects of varying the interval between courses of methotrexate on its myelotoxic and anti-leukaemic activities.

7. A rodent model for testicular involvement in acute lymphoblastic leukaemia.

8. Testicular invasion and relapse and meningeal involvement in a rat T-cell leukaemia.

9. Location of T-cell leukaemia cells in a model rat system by means of a fluorescent probe.