Literature DB >> 10816546

A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice.

J H Allen1, M Utley, H van Den Bosch, P Nuijten, M Witvliet, B A McCormick, K A Krogfelt, T R Licht, D Brown, M Mauel, M P Leatham, D C Laux, P S Cohen.   

Abstract

A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

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Year:  2000        PMID： 10816546      PMCID： PMC97677          DOI： 10.1128/IAI.68.6.3772-3775.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2.

Authors:  K Jahreis; P W Postma; J W Lengeler
Journal:  Mol Gen Genet       Date:  1991-04

2.  Plasmid vector pBR322 and its special-purpose derivatives--a review.

Authors:  P Balbás; X Soberón; E Merino; M Zurita; H Lomeli; F Valle; N Flores; F Bolivar
Journal:  Gene       Date:  1986       Impact factor: 3.688

3.  Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents.

Authors:  T R Licht; T Tolker-Nielsen; K Holmstrøm; K A Krogfelt; S Molin
Journal:  Environ Microbiol       Date:  1999-02       Impact factor: 5.491

4.  Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic.

Authors:  R Curtiss; S M Kelly
Journal:  Infect Immun       Date:  1987-12       Impact factor: 3.441

5.  Roles of motility, chemotaxis, and penetration through and growth in intestinal mucus in the ability of an avirulent strain of Salmonella typhimurium to colonize the large intestine of streptomycin-treated mice.

Authors:  B A McCormick; B A Stocker; D C Laux; P S Cohen
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

6.  Characterization of Tn10d-Cam: a transposition-defective Tn10 specifying chloramphenicol resistance.

Authors:  T Elliott; J R Roth
Journal:  Mol Gen Genet       Date:  1988-08

7.  Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.

Authors:  S I Miller; J J Mekalanos
Journal:  J Bacteriol       Date:  1990-05       Impact factor: 3.490

8.  Altered transcriptional patterns affecting several metabolic pathways in strains of Salmonella typhimurium which overexpress the fructose regulon.

Authors:  A M Chin; D A Feldheim; M H Saier
Journal:  J Bacteriol       Date:  1989-05       Impact factor: 3.490

9.  Phosphatidylserine found in intestinal mucus serves as a sole source of carbon and nitrogen for salmonellae and Escherichia coli.

Authors:  H C Krivan; D P Franklin; W Wang; D C Laux; P S Cohen
Journal:  Infect Immun       Date:  1992-09       Impact factor: 3.441

10.  A Salmonella typhimurium mutant unable to utilize fatty acids and citrate is avirulent and immunogenic in mice.

Authors:  M Utley; D P Franklin; K A Krogfelt; D C Laux; P S Cohen
Journal:  FEMS Microbiol Lett       Date:  1998-06-15       Impact factor: 2.742
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  12 in total

1.  The interacting Cra and KdpE regulators are involved in the expression of multiple virulence factors in enterohemorrhagic Escherichia coli.

Authors:  Jacqueline W Njoroge; Charley Gruber; Vanessa Sperandio
Journal:  J Bacteriol       Date:  2013-03-22       Impact factor: 3.490

2.  Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.

Authors:  Samuel A Shelburne; Pranoti Sahasrobhajane; Bryce Suber; David B Keith; Michael T Davenport; Nicola Horstmann; Muthiah Kumaraswami; Randall J Olsen; Richard G Brennan; James M Musser
Journal:  Mol Microbiol       Date:  2011-06-05       Impact factor: 3.501

3.  Role of gluconeogenesis and the tricarboxylic acid cycle in the virulence of Salmonella enterica serovar Typhimurium in BALB/c mice.

Authors:  Merlin Tchawa Yimga; Mary P Leatham; James H Allen; David C Laux; Tyrrell Conway; Paul S Cohen
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441

4.  Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes.

Authors:  Melissa A Ramírez; Michael C Lorenz
Journal:  Eukaryot Cell       Date:  2006-12-08

5.  Xanthomonas campestris pv. campestris possesses a single gluconeogenic pathway that is required for virulence.

Authors:  Dong-Jie Tang; Yong-Qiang He; Jia-Xun Feng; Bao-Ren He; Bo-Le Jiang; Guang-Tao Lu; Baoshan Chen; Ji-Liang Tang
Journal:  J Bacteriol       Date:  2005-09       Impact factor: 3.490

Review 6.  Allostery in the LacI/GalR family: variations on a theme.

Authors:  Liskin Swint-Kruse; Kathleen S Matthews
Journal:  Curr Opin Microbiol       Date:  2009-03-05       Impact factor: 7.934

7.  Salmonella enterica serovar Typhimurium mutants unable to convert malate to pyruvate and oxaloacetate are avirulent and immunogenic in BALB/c mice.

Authors:  Regino Mercado-Lubo; Mary P Leatham; Tyrrell Conway; Paul S Cohen
Journal:  Infect Immun       Date:  2009-01-21       Impact factor: 3.441

8.  A Salmonella enterica serovar typhimurium succinate dehydrogenase/fumarate reductase double mutant is avirulent and immunogenic in BALB/c mice.

Authors:  Regino Mercado-Lubo; Eric J Gauger; Mary P Leatham; Tyrrell Conway; Paul S Cohen
Journal:  Infect Immun       Date:  2007-12-17       Impact factor: 3.441

9.  RNA-seq analysis of the influence of anaerobiosis and FNR on Shigella flexneri.

Authors:  Marta Vergara-Irigaray; Maria C Fookes; Nicholas R Thomson; Christoph M Tang
Journal:  BMC Genomics       Date:  2014-06-06       Impact factor: 3.969

10.  Coordinated regulation of virulence during systemic infection of Salmonella enterica serovar Typhimurium.

Authors:  Hyunjin Yoon; Jason E McDermott; Steffen Porwollik; Michael McClelland; Fred Heffron
Journal:  PLoS Pathog       Date:  2009-02-20       Impact factor: 6.823
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