Literature DB >> 10816538

Interaction of human phagocytes with pigmentless Aspergillus conidia.

B Jahn1, F Boukhallouk, J Lotz, K Langfelder, G Wanner, A A Brakhage.   

Abstract

A defect in the pksP gene of Aspergillus fumigatus is associated with the loss of conidial pigmentation, a profound change of the conidial surface structure, and reduced virulence. The structural change of the conidial surface structure was not observed in similar A. nidulans wA mutants. Our data indicate that the pigment of both species is important for scavenging reactive oxygen species and for protection of conidia against oxidative damage.

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Year:  2000        PMID： 10816538      PMCID： PMC97669          DOI： 10.1128/IAI.68.6.3736-3739.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  17 in total

1.  The developmentally regulated Aspergillus nidulans wA gene encodes a polypeptide homologous to polyketide and fatty acid synthases.

Authors:  M E Mayorga; W E Timberlake
Journal:  Mol Gen Genet       Date:  1992-11

2.  Regulation of Aspergillus nidulans penicillin biosynthesis and penicillin biosynthesis genes acvA and ipnA by glucose.

Authors:  A A Brakhage; P Browne; G Turner
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

Review 3.  Aspergillus fumigatus and aspergillosis.

Authors:  J P Latgé
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

4.  Mechanisms of resistance of Aspergillus fumigatus Conidia to killing by neutrophils in vitro.

Authors:  S M Levitz; R D Diamond
Journal:  J Infect Dis       Date:  1985-07       Impact factor: 5.226

5.  Redox buffering by melanin and Fe(II) in Cryptococcus neoformans.

Authors:  E S Jacobson; J D Hong
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

6.  Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence.

Authors:  B Jahn; A Koch; A Schmidt; G Wanner; H Gehringer; S Bhakdi; A A Brakhage
Journal:  Infect Immun       Date:  1997-12       Impact factor: 3.441

7.  A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus.

Authors:  H F Tsai; M H Wheeler; Y C Chang; K J Kwon-Chung
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

8.  Antioxidant function of melanin in black fungi.

Authors:  E S Jacobson; E Hove; H S Emery
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

9.  Pathogenicity and virulence of wild-type and melanin-deficient Wangiella dermatitidis.

Authors:  D M Dixon; A Polak; P J Szaniszlo
Journal:  J Med Vet Mycol       Date:  1987-04

10.  Cryptococcus neoformans melanin and virulence: mechanism of action.

Authors:  Y Wang; P Aisen; A Casadevall
Journal:  Infect Immun       Date:  1995-08       Impact factor: 3.441
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  37 in total

Review 1.  Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts.

Authors:  Tricia A Missall; Jennifer K Lodge; Joan E McEwen
Journal:  Eukaryot Cell       Date:  2004-08

2.  LaeA, a regulator of morphogenetic fungal virulence factors.

Authors:  Jin Woo Bok; S Arunmozhi Balajee; Kieren A Marr; David Andes; Kristian Fog Nielsen; Jens C Frisvad; Nancy P Keller
Journal:  Eukaryot Cell       Date:  2005-09

3.  Putative polyketide synthase and laccase genes for biosynthesis of aurofusarin in Gibberella zeae.

Authors:  Jung-Eun Kim; Kap-Hoon Han; Jianming Jin; Hun Kim; Jin-Cheol Kim; Sung-Hwan Yun; Yin-Won Lee
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

4.  Melanogenesis in dermatophyte species in vitro and during infection.

Authors:  Sirida Youngchim; Soraya Pornsuwan; Joshua D Nosanchuk; Wiyada Dankai; Nongnuch Vanittanakom
Journal:  Microbiology (Reading)       Date:  2011-05-12       Impact factor: 2.777

5.  Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence.

Authors:  Dimitrios I Tsitsigiannis; Jin-Woo Bok; David Andes; Kristian Fog Nielsen; Jens C Frisvad; Nancy P Keller
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

6.  Differential expression of the Aspergillus fumigatus pksP gene detected in vitro and in vivo with green fluorescent protein.

Authors:  K Langfelder; B Philippe; B Jahn; J P Latgé; A A Brakhage
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441

Review 7.  Allergic bronchopulmonary aspergillosis.

Authors:  Richard B Moss
Journal:  Clin Rev Allergy Immunol       Date:  2002-08       Impact factor: 8.667

8.  cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages.

Authors:  B Liebmann; S Gattung; B Jahn; A A Brakhage
Journal:  Mol Genet Genomics       Date:  2003-05-07       Impact factor: 3.291

9.  The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus.

Authors:  Burghard Liebmann; Meike Müller; Armin Braun; Axel A Brakhage
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

10.  Aspergillus fumigatus conidial melanin modulates host cytokine response.

Authors:  Louis Y A Chai; Mihai G Netea; Janyce Sugui; Alieke G Vonk; Wendy W J van de Sande; Adilia Warris; Kyung J Kwon-Chung; Bart Jan Kullberg
Journal:  Immunobiology       Date:  2009-11-25       Impact factor: 3.144
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