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Literature DB >> 10816532

Interaction of Shigella flexneri IpaC with model membranes correlates with effects on cultured cells.

N Tran¹, A B Serfis, J C Osiecki, W L Picking, L Coye, R Davis, W D Picking.

Abstract

Invasion of enterocytes by Shigella flexneri requires the properly timed release of IpaB and IpaC at the host-pathogen interface; however, only IpaC has been found to possess quantifiable activities in vitro. We demonstrate here that when added to cultured cells, purified IpaC elicits cytoskeletal changes similar to those that occur during Shigella invasion. This IpaC effect may correlate with its ability to interact with model membranes at physiological pH and to promote entry by an ipaC mutant of S. flexneri.

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Year: 2000 PMID： 10816532 PMCID： PMC97663 DOI： 10.1128/IAI.68.6.3710-3715.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells.

Authors: G Tran Van Nhieu; E Caron; A Hall; P J Sansonetti
Journal: EMBO J Date: 1999-06-15 Impact factor: 11.598

Review 2. Type III secretion machines: bacterial devices for protein delivery into host cells.

Authors: J E Galán; A Collmer
Journal: Science Date: 1999-05-21 Impact factor: 47.728

Review 3. Cross-talk between bacterial pathogens and their host cells.

Authors: J E Galán; J B Bliska
Journal: Annu Rev Cell Dev Biol Date: 1996 Impact factor: 13.827

4. Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation.

Authors: P Clerc; P J Sansonetti
Journal: Infect Immun Date: 1987-11 Impact factor: 3.441

5. Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes.

Authors: C De Geyter; B Vogt; Z Benjelloun-Touimi; P J Sansonetti; J M Ruysschaert; C Parsot; V Cabiaux
Journal: FEBS Lett Date: 1997-01-03 Impact factor: 4.124

6. Cloning, expression, and affinity purification of recombinant Shigella flexneri invasion plasmid antigens IpaB and IpaC.

Authors: W L Picking; J A Mertz; M E Marquart; W D Picking
Journal: Protein Expr Purif Date: 1996-12 Impact factor: 1.650

7. The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells.

Authors: R Ménard; M C Prévost; P Gounon; P Sansonetti; C Dehio
Journal: Proc Natl Acad Sci U S A Date: 1996-02-06 Impact factor: 11.205

8. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells.

Authors: R Ménard; P J Sansonetti; C Parsot
Journal: J Bacteriol Date: 1993-09 Impact factor: 3.490

9. IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

Authors: N High; J Mounier; M C Prévost; P J Sansonetti
Journal: EMBO J Date: 1992-05 Impact factor: 11.598

10. Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells.

Authors: M Watarai; S Funato; C Sasakawa
Journal: J Exp Med Date: 1996-03-01 Impact factor: 14.307

8 in total

8. The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells.

Authors: Joëlle Mounier; Michel R Popoff; Jost Enninga; Margaret C Frame; Philippe J Sansonetti; Guy Tran Van Nhieu
Journal: PLoS Pathog Date: 2009-01-23 Impact factor: 6.823

8 in total

Interaction of Shigella flexneri IpaC with model membranes correlates with effects on cultured cells.

1. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells.

Review 2. Type III secretion machines: bacterial devices for protein delivery into host cells.

Review 3. Cross-talk between bacterial pathogens and their host cells.

4. Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation.

5. Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes.

6. Cloning, expression, and affinity purification of recombinant Shigella flexneri invasion plasmid antigens IpaB and IpaC.

7. The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells.

8. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells.

9. IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

10. Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells.

1. Characterization of molten globule PopB in absence and presence of its chaperone PcrH.

2. Structural characterization of the N terminus of IpaC from Shigella flexneri.

3. IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.

4. Detergent Isolation Stabilizes and Activates the Shigella Type III Secretion System Translocator Protein IpaC.

5. The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells.

6. Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast.

Review 7. The Shigella Type III Secretion System: An Overview from Top to Bottom.

8. The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells.